Primary Information |
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| BoMiProt ID | Bomi9192 |
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| Protein Name | Sine oculis-binding protein homolog |
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| Organism | Bos taurus |
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| Uniprot ID | A7XYH9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001094640.2 |
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| Aminoacid Length | 872 |
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| Molecular Weight | 92469 |
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| FASTA Sequence |
Download |
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| Gene Name | SOBP |
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| Gene ID | 537433 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | critical for cochlear growth, cell fate, and patterning of the organ of corti |
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| Biochemical Properties | nuclear zinc finger protein. two proline-rich sequences (amino acids 346 –543 and 695–745), two nuclear localization signals
(amino acids 11–18 and 851–858), and two domains that are
closely related to the phenylalanine-cysteine-serine (FCS)-type
zinc finger proteins. |
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| PTMs | Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7XYH9|SOBP_BOVIN Sine oculis-binding protein homolog OS=Bos taurus OX=9913 GN=SOBP PE=2 SV=1
MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIE
FRSYPTDGESRQHISVLKENSLPKPKLPEDSVISPYNISTGYSGLATGNGLSDSPAGSKD
HGNVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFA
ACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLVCDWCKHIRHTKEYLDF
GDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCSTLHPPMENKTEGTGVQLLTPDSW
NIPLTDARRKAPSPVAAAGQSQGPGPSASTTVSPSDTANCSVTKIPTPVPKSMPISETPN
IPPVSVQPPASIGPPLGVPPRSPPMVMTNRGPVPLPIFMEQQIMQQLRPPFIRGPPHHAS
NPNSPLSNPMLPGIGPPPGGPRNLGPTSSPMHRPLLSPHIHPPSTPTMPGNPPGLLPPPP
PGAPLPSLPFPPVSMMPNGPMPVPQMMNFGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIP
IPVPHVSDSKPPNGFSSNGENFIPSAPGDSSAAGGKPGGHSLSPRDSKQGSSKSADSPPG
CSGQALSLAPAPAEHGRSEVVDLTRRAGS*629PPGAGGQLGFPGGVLQGPQDGVIDLTVGHRA
RLHNVIHRALHAHVKAEREPGAAERRTCGGCRDGHCS*697PPAAGDPGPGAPAGPEAAAACNV
IVNGTRGAAEGAKGAEPPPEQPPPPPPPPPAPPKKLLSPEEPAVSELESVKENNCASNCH
LDGEAAKKLMGEEALAGGDKSDPNLNNPADEDHAYALRMLPKTGCVIQPVPKPAEKAAMA
PCIISSPMLSAGPEDLEPPLKRRCLRIRNQNK
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| Predicted Disorder Regions | 4 disordered segments; (308-317), (578-603), (681-706), (712-803) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Chen Z, Montcouquiol M, Calderon R, Jenkins NA, Copeland NG, Kelley MW, Noben-Trauth K. Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. J Neurosci. 2008 Jun 25;28(26):6633-41. doi: 10.1523/JNEUROSCI.1280-08.2008. PMID: 18579736; PMCID: PMC2556235. |
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