Primary Information |
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| BoMiProt ID | Bomi9179 |
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| Protein Name | Signal transducer and activator of transcription 5A/Mammary gland factor |
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| Organism | Bos taurus |
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| Uniprot ID | Q95115 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001012691.1 |
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| Aminoacid Length | 794 |
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| Molecular Weight | 90700 |
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| FASTA Sequence |
Download |
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| Gene Name | STAT5A/MGF |
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| Gene ID | 282375 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.mediates the biological actions of members of the γ(c) family of cytokines in the immune system. |
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| Significance in milk | has a crucial role in the regulation of cell death during mammary gland involution.Regulates the expression of milk proteins during lactation |
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| PTMs | Phosphorylation on tyrosine and Serine. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q95115|STA5A_BOVIN Signal transducer and activator of transcription 5A OS=Bos taurus OX=9913 GN=STAT5A PE=2 SV=2
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHY*90ATQLQNTYDRCPMELVRCIRHILYNEQRLV
REANNGSS*128SAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFAQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNS
SSSHLEDYNGMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRL
GDLNYLIYVFPDRPKDEVFSKY*682YTPVLAKAVDGY*694VKPQIKQVVPEFVSASADSAGSNATY
MDQAPSPAVCPQPHYNMYPQNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLEPSLP
PPTGLFTPGRGSLS
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| Predicted Disorder Regions | 2 predicted disordered segments;(712-750), (774-794) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Tyrosine phosphorylation is required for DNA-binding activity and dimerization.Serine phosphorylation is also required for maximal transcriptional activity |
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