Search by BoMiProt ID - Bomi9172

Primary Information

BoMiProt ID Bomi9172
Protein Name Signal recognition particle 54 kDa protein
Organism Bos taurus
Uniprot IDQ2T9U1
Milk FractionWhey
Ref Sequence ID NP_001033290.1
Aminoacid Length 504
Molecular Weight 55705
FASTA Sequence Download
Gene Name SRP54
Protein Existence Status reviewed

Secondary Information

Protein Function insertion of most membrane proteins at the ER membrane
Biochemical Properties This insertion into ER membrane depends upon SRP binding to the conserved N-terminal signal sequences and internal signal anchors of target protein.A contiguous stretch of 7–15 hydrophobic residues interacts with SRP.SRP 54 contains 3 domains,N,G amd M domain.N domain is 4 helix bundle while G domains has Ras like GTPase activity.N and G domains are necessary for binding of SRP to SrP receptor.The carboxyl-terminal M domain contains the SRP RNA-binding site and is required for binding to signal sequences.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography 1.Keenan RJ, Freymann DM, Walter P, Stroud RM. Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell. 1998 Jul 24;94(2):181-91. doi: 10.1016/s0092-8674(00)81418-x. PMID: 9695947. 2.Abell BM, Pool MR, Schlenker O, Sinning I, High S. Signal recognition particle mediates post-translational targeting in eukaryotes. EMBO J. 2004 Jul 21;23(14):2755-64. doi: 10.1038/sj.emboj.7600281. Epub 2004 Jul 1. PMID: 15229647; PMCID: PMC514945.