Search by BoMiProt ID - Bomi9169

Primary Information

BoMiProt ID Bomi9169
Protein Name Signal peptidase complex subunit 1/Microsomal signal peptidase 12 kDa subunit
Organism Bos taurus
Uniprot IDQ3T134
Milk FractionWhey
Ref Sequence ID NP_001029576.1
Aminoacid Length 102
Molecular Weight 11805
FASTA Sequence Download
Gene Name SPCS1
Gene ID 511453
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells prostate gland 
Protein Function SPCS1 plays a key role in the formation of the membrane-associated NS2-E2 complex via its interaction with NS2 and E2, which leads to a coordinating interaction between the structural and non-structural proteins and facilitates the early step of assembly of infectious particles.
PTMs phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-14, 77-102
DisProt Annotation
TM Helix Prediction 2TMHs; (23-41) & (48-70)
Additional Comments Silencing of endogenous SPCS1 resulted in markedly reduced production of infectious HCV, whereas neither processing of structural proteins, cell entry, RNA replication, nor release of virus from the cells was impaired.
Bibliography 1.Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. PLoS Pathog. 2013;9(8):e1003589. doi: 10.1371/journal.ppat.1003589. Epub 2013 Aug 29. PMID: 24009510; PMCID: PMC3757040.