Primary Information |
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| BoMiProt ID | Bomi9169 |
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| Protein Name | Signal peptidase complex subunit 1/Microsomal signal peptidase 12 kDa subunit |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T134 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029576.1 |
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| Aminoacid Length | 102 |
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| Molecular Weight | 11805 |
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| FASTA Sequence |
Download |
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| Gene Name | SPCS1 |
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| Gene ID | 511453 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | prostate gland |
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| Protein Function | SPCS1 plays a key role in the formation of the membrane-associated NS2-E2 complex via its interaction with NS2 and E2, which leads to a coordinating interaction between the structural and non-structural proteins and facilitates the early step of assembly of infectious particles. |
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| PTMs | phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-14, 77-102 |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (23-41) & (48-70) |
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| Additional Comments | Silencing of endogenous SPCS1 resulted in markedly reduced production of infectious HCV, whereas neither processing of structural proteins, cell entry, RNA replication, nor release of virus from the cells was impaired. |
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| Bibliography | 1.Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. PLoS Pathog. 2013;9(8):e1003589. doi: 10.1371/journal.ppat.1003589. Epub 2013 Aug 29. PMID: 24009510; PMCID: PMC3757040. |
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