Primary Information |
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| BoMiProt ID | Bomi9148 |
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| Protein Name | Short-chain specific acyl-CoA dehydrogenase, mitochondrial/Butyryl-CoA dehydrogenase |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBF6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029573.1 |
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| Aminoacid Length | 412 |
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| Molecular Weight | 44552 |
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| FASTA Sequence |
Download |
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| Gene Name | ACADS |
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| Gene ID | 511222 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | catalyze the first step of mitochondrial fatty acid beta-oxidation.production of energy from fats. introduce a trans-otp-double-bond
into saturated acyl-CoA substrates during beta-oxidation |
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| Biochemical Properties | a tetramer with a native Mr of approx. 162 000 and a subunit Mr of 41 000 |
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| Significance in milk | regulate the metabolism of milk fat in dairy cattle. |
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| PTMs | Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3ZBF6|ACADS_BOVIN Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=ACADS PE=1 SV=1
MAATLLARACGLVRGAPWPWGWRRLHT*27VYQSVELPETHQMLRQTCRDFAEKELFPIAAQV
DKEHRFPAAQVKKMGELGLMAMNVPEELSGAGLDYLAYSIAMEEISRGCASTGVIMSVNN
SLYLGPILKFGTKEQKQQWVAPFTSGDKIGCFALSEPGNGSDAGAAATTARADGDSWVLS
GTKAWITNAWEASAVVVFASTDRSLHNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN
LIFEDRRIPKDSLLGEPGLGFKIAMQTLDTGRIGIASQALGIAQAALDCAVTYAENRSAF
GAPLTKLQAIQFKLADMALALESARLLTWRAAMLKDNKKPFTKEAAMAKLAASEAATAIT
HQAMQILGGMGYVKEMPAERHYRDARITEIYEGTSEIQRLVVAGHLLKSYRS
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| Predicted Disorder Regions | 1 disordered segment; (1-9) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Shaw L, Engel PC. The purification and properties of ox liver short-chain acyl-CoA dehydrogenase. Biochem J. 1984 Mar 1;218(2):511-20. doi: 10.1042/bj2180511. PMID: 6712627; PMCID: PMC1153367. |
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