Primary Information |
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| BoMiProt ID | Bomi9132 |
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| Protein Name | SH3KBP1-binding protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A3KMV1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001076076.1 |
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| Aminoacid Length | 704 |
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| Molecular Weight | 75885 |
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| FASTA Sequence |
Download |
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| Gene Name | SHKBP1 |
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| Gene ID | 512402 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | promote EGFR signaling pathway by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. |
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| Biochemical Properties | contains two PXXXPR motifs, which are bound to SH3 domains of CIN85. binding of SHKBP1 prevented the interaction of CIN85 with c-Cbl and inhibited the translocation of CIN85 to EGFR-containing vesicles. |
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| PTMs | Acetylation on Ala and phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A3KMV1|SHKB1_BOVIN SH3KBP1-binding protein 1 OS=Bos taurus OX=9913 GN=SHKBP1 PE=2 SV=1
MAAAAPAVDGVPGRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDET
GAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLLEELDRSS
CGNVLFTGYLPPPVFPVKRRNRHSLVGPQQAGGRPAPVRRSNT*163MPPNLGNAGLLGRMLDE
KSPPSPSGLPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIER
LALTARVLGGALGEHDKMVAVATGSEILLWALQPEGGGSEIGVFHLGVPVEALFFVGNQL
IATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKD
NDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGP
QLFQTFTVHRSPVTKIMLSEKHLISVCADSNHVRTWSVTRFRGMISTQPGSTPLASFKIL
ALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGS
PTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEEELME
QLEQCDLAPLASSRGSLPSPSPRTSLTSLHSAFSNTSLSSRRGS*644PS*646PPQAEARRRGGGSF
VERCQELVRSGPEPRRPPTPAPRPSSGLGAPLVPPKTKLNETSF |
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| Predicted Disorder Regions | 5 disordered segments; (1-13), (148-168), (491-496), (590-646), (684-704) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Feng L, Wang JT, Jin H, Qian K, Geng JG. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Cell Biochem Funct. 2011 Oct;29(7):589-96. doi: 10.1002/cbf.1792. Epub 2011 Aug 9. PMID: 21830225; PMCID: PMC4534006. |
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