Primary Information |
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| BoMiProt ID | Bomi9130 |
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| Protein Name | SH3 domain-binding glutamic acid-rich-like protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A4IFC4 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001077260.1 |
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| Aminoacid Length | 107 |
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| Molecular Weight | 12292 |
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| FASTA Sequence |
Download |
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| Gene Name | SH3BGRL2 |
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| Gene ID | 785404 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A novel tumour suppressor.Loss of SH3BGRL2 was found to activate Hippo / TEAD1 / Twist1 signaling pathway and promote aggressiveness of clear cell renal cell carcinomas (ccRCC). |
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| Biochemical Properties | These small proteins contain a thioredoxin-like fold, SH3 binding domain, and glutamate-rich domain. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-3, 7-14, 46-73, 99-107 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | In Kaposi's Sarcoma, the loss of SH3BGR is due to expression of miR-K6-3p and induces cell migration and angiogenesis.when SH3BGRL is mutated (R76C), it binds and activates SRC and promotes metastasis. |
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| Bibliography | 1.Dufies M. SH3BGRL2, a new downregulated tumor suppressor in clear cell renal cell carcinomas. EBioMedicine. 2020 Feb;52:102641. doi: 10.1016/j.ebiom.2020.102641. Epub 2020 Jan 31. PMID: 32014821; PMCID: PMC6997511. |
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