Primary Information |
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| BoMiProt ID | Bomi9063 |
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| Protein Name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform/Medium tumor antigen-associated 61 kDa protein/PP2A subunit A isoform PR65-alpha/PP2A subunit A isoform R1-alpha |
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| Organism | Bos taurus |
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| Uniprot ID | Q32PI5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001032554.1 |
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| Aminoacid Length | 589 |
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| Molecular Weight | 65291 |
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| FASTA Sequence |
Download |
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| Gene Name | PPP2R1A |
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| Gene ID | 535321 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT.Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis |
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| Biochemical Properties | Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction. |
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| PTMs | Disulfide bond formation and N-Linked Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | It is over-expressed in melanocytes. |
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| Bibliography | 1.Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM. Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem. 2004 Dec 31;279(53):54983-6. doi: 10.1074/jbc.C400508200. Epub 2004 Nov 3. PMID: 15525651. 2.Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 2006 May;10(5):575-85. doi: 10.1016/j.devcel.2006.03.010. Epub 2006 Mar 30. PMID: 16580887. |
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