Search by BoMiProt ID - Bomi9063

Primary Information

BoMiProt ID Bomi9063
Protein Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform/Medium tumor antigen-associated 61 kDa protein/PP2A subunit A isoform PR65-alpha/PP2A subunit A isoform R1-alpha
Organism Bos taurus
Uniprot IDQ32PI5
Milk FractionWhey
Ref Sequence ID NP_001032554.1
Aminoacid Length 589
Molecular Weight 65291
FASTA Sequence Download
Gene Name PPP2R1A
Gene ID 535321
Protein Existence Status reviewed

Secondary Information

Protein Function The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT.Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis
Biochemical Properties Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
PTMs Disulfide bond formation and N-Linked Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments It is over-expressed in melanocytes.
Bibliography 1.Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM. Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem. 2004 Dec 31;279(53):54983-6. doi: 10.1074/jbc.C400508200. Epub 2004 Nov 3. PMID: 15525651. 2.Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 2006 May;10(5):575-85. doi: 10.1016/j.devcel.2006.03.010. Epub 2006 Mar 30. PMID: 16580887.