Primary Information |
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| BoMiProt ID | Bomi9047 |
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| Protein Name | Serine/threonine-protein kinase haspin/Germ cell-specific gene 2 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KIP2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070012.1 |
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| Aminoacid Length | 781 |
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| Molecular Weight | 86411 |
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| FASTA Sequence |
Download |
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| Gene Name | HASPIN/GSG2 |
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| Gene ID | 767819 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is responsible for phosphorylation of histone H3 at threonine 3 (H3T3ph) during mitosis, in mammals and yeast.Also involved in sister chromatid cohesion during mitosis. |
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| Biochemical Properties | Mg2+ as cofactor. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KIP2|HASP_BOVIN Serine/threonine-protein kinase haspin OS=Bos taurus OX=9913 GN=HASPIN PE=2 SV=1
MAASLPLPASGLFRTYGAAGGGRPRRRQGLAAVQWFPPQDRKRFFSSSSSDTSSGGPS*58QS
VVSDDPDDPDFPGSPVGQRRRRAGARLAKGRPS*93QIATPRRLRLRSRCPQKCSTPCGALEP
PSFPNGNPGSLS*132PDLRVCGQPRDGGELGTSASLFSSLASPGPGFPAPEDSICTDPSTFLD
AASEAPSNFHLPEASLDQAPLPCSQDAATGGGRFTRLAHQAQASLRSALFSFLDPGNPED
SELGTDGKNLQEFCHDRELVGRRLESPGLSGRGKKRTTDQDSCREIESQESVQIEYEEAR
GCKGGIASGKSNGPERTRLSRKRKHQGTAETSLLHHCQVTKGQKMEDGSCVTQDLTRLQN
ACSWTKTRASFSFHKKKIVTAVSEVCSCDTLAGSLSESLMSEYSHHPVQNRTSCALSPWH
SSSMYLLTPLKTQQVTDKRTSDAEKLYGECNQVGPIPFSDYLSEEKLECCEKIGEGVFGE
VFQTVTNHTPVALKIIAIEGQNLVNGAHQKTFEEILPEIIISKELSLLSDEACNRTEGFI
GLNSVHCVQGSYPPLLLQAWDHYHSTKGSANDRPDFFREDQLFIVLEFEFGGIDLEQMRK
KLSSIATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTSLKELHYTLNGKKSSIP
TRGLQVNIIDYTLSRLERDGIVVFCDISRDEDLFMGQGDYQFEIYRLMRKENNNCWGEYH
PYNNVLWLHYLTDKILNQMTFKSKHNTPALKRMKKQIQHFYQTMLNFSSATDLLCQHSLF
K |
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| Predicted Disorder Regions | 39-95, 110-115, 143-210, 238-242, 265-289, 310-333 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Autophosphorylated on both serine and threonine residues which is imp for cell cycle regulation.Approx 30 mitotic phosphorylation sites in the N-terminal domain of human haspin have been identified.Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.Phosphorylation of haspin on its N-domain may alter the access of haspin to its substrates, or might regulate the interaction of haspin with putative regulatory proteins that control its activity in cells. |
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| Bibliography | 1.Fresán U, Rodríguez-Sánchez MA, Reina O, Corces VG, Espinàs ML. Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing. PLoS Genet. 2020 Aug 4;16(8):e1008962. doi: 10.1371/journal.pgen.1008962. PMID: 32750047; PMCID: PMC7428214. 2.Higgins JM. Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma. 2010 Apr;119(2):137-47. doi: 10.1007/s00412-009-0250-4. Epub 2009 Dec 8. PMID: 19997740; PMCID: PMC2839057. |
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