Primary Information |
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| BoMiProt ID | Bomi9037 |
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| Protein Name | Serine/arginine-rich splicing factor 1/Splicing factor, arginine/serine-rich 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VCY7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069862.1 |
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| Aminoacid Length | 248 |
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| Molecular Weight | 27745 |
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| FASTA Sequence |
Download |
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| Gene Name | SRSF1 |
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| Gene ID | 615796 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | abdominal lymph node |
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| Protein Function | Serine/arginine-rich splicing factor 1 (SRSF1) has been linked to various human cancers including pediatric acute lymphoblastic leukemia (ALL).Serine/arginine‐rich splicing factor 1 is also connected to genomic instability, cell‐cycle arrest, and apoptosis. |
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| PTMs | Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0VCY7|SRSF1_BOVIN Serine/arginine-rich splicing factor 1 OS=Bos taurus OX=9913 GN=SRSF1 PE=2 SV=1
MS*2GGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE
FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE
NRVVVSGLPPSGS*133WQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF
RSHEGETAYIRVKVDGPRS*199PS*201Y*202GRS*205RS*207RS*209RSRSRSRSRSNSRSRSYSPRRS*231RGS*234PRYS*238PRHSRSRSRT
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| Predicted Disorder Regions | 1-11, 89-103, 190-248 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Methylation by PRMT1 promotes localization to nuclear speckles.Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation and distributive phosphorylation steps. |
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| Bibliography | 1.Xu L, Zhang H, Mei M, Du C, Huang X, Li J, Wang Y, Bao S, Zheng H. Phosphorylation of serine/arginine-rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia. Cancer Sci. 2018 Dec;109(12):3805-3815. doi: 10.1111/cas.13834. Epub 2018 Nov 14. PMID: 30320932; PMCID: PMC6272096. 2.Das S, Krainer AR. Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Mol Cancer Res. 2014;12:1195‐1204. |
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