Search by BoMiProt ID - Bomi9035

Primary Information

BoMiProt ID Bomi9035
Protein Name Serine protease HTR4/High-temperature requirement factor A4
Organism Bos taurus
Uniprot IDE1BJW1
Milk FractionWhey
Aminoacid Length 484
Molecular Weight 51220
FASTA Sequence Download
Gene Name HTRA4
Protein Existence Status reviewed

Secondary Information

Protein Function participates in oncogenesis and placentation, and plays a role in preeclampsia. Proapoptotic in function.
Biochemical Properties The N-terminal region, dispensable for proteolytic function,is followed by a chymotrypsin-like protease domain(PD) containing a catalytic triad formed by the His, Asp, Ser and by a PDZ (Postsynaptic density protein 95, Drosophila disc large tumor suppressor and Zonula occludens-1 protein domain 1) domain.XIAP, caspases 7 and 9, β-tubulin, actin, TCP1α and S100A6 are partners of HtrA4.
PTMs Disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Wenta T, Jarzab M, Rychlowski M, Borysiak M, Latala A, Zurawa-Janicka D, Filipek A, Lipinska B. Cellular substrates and pro-apoptotic function of the human HtrA4 protease. J Proteomics. 2019 Oct 30;209:103505. doi: 10.1016/j.jprot.2019.103505. Epub 2019 Aug 27. PMID: 31470122.