Primary Information |
|---|
| BoMiProt ID | Bomi9035 |
|---|
| Protein Name | Serine protease HTR4/High-temperature requirement factor A4 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | E1BJW1 |
|---|
| Milk Fraction | Whey |
|---|
| Aminoacid Length | 484 |
|---|
| Molecular Weight | 51220 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | HTRA4 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | participates in oncogenesis and placentation, and plays a role in preeclampsia. Proapoptotic in function. |
|---|
| Biochemical Properties | The N-terminal region, dispensable for proteolytic function,is followed by a chymotrypsin-like protease domain(PD) containing a catalytic triad formed by the His, Asp, Ser and by a PDZ (Postsynaptic density protein 95, Drosophila disc large tumor suppressor and Zonula occludens-1 protein domain 1) domain.XIAP, caspases 7 and 9, β-tubulin, actin, TCP1α and S100A6 are partners of HtrA4. |
|---|
| PTMs | Disulfide bond formation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | 1.Wenta T, Jarzab M, Rychlowski M, Borysiak M, Latala A, Zurawa-Janicka D, Filipek A, Lipinska B. Cellular substrates and pro-apoptotic function of the human HtrA4 protease. J Proteomics. 2019 Oct 30;209:103505. doi: 10.1016/j.jprot.2019.103505. Epub 2019 Aug 27. PMID: 31470122. |
|---|
