Primary Information
BoMiProt ID	Bomi9029
Protein Name	Serine hydroxymethyltransferase, mitochondrial/Glycine hydroxymethyltransferase/Serine methylase
Organism	Bos taurus
Uniprot ID	Q3SZ20
Milk Fraction	Whey
Ref Sequence ID	NP_001029454.1
Aminoacid Length	504
Molecular Weight	55605
FASTA Sequence	Download
Gene Name	SHMT2
Gene ID	507197
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	placenta
Protein Function	One of the isoforms of the enzyme Serine hydroxymethyltransferase (SHMT),which catalyzes the reversible conversion of l-serine and tetrahydrofolate into glycine and 5,10-methylenetetrahydrofolate. This enzyme, which plays a pivotal role in one-carbon metabolism, is involved in cancer metabolic reprogramming and is a recognized target of chemotherapy intervention.
PTMs	N6-acetylation at Lysine,Phosphorylation at Serine,Succinylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Succinylation at Lys-280 inhibits the hydroxymethyltransferase activity.
Additional Comments	SHMT2 is overexpressed in liver cancer, lung cancer, and breast cancer and is associated with a poor prognosis
Bibliography	1.Tramonti A, Nardella C, di Salvo ML, Barile A, Cutruzzolà F, Contestabile R. Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties. Biochemistry. 2018 Dec 26;57(51):6984-6996. doi: 10.1021/acs.biochem.8b01074. Epub 2018 Dec 7. PMID: 30500180. 2. C.C. Woo, W.C. Chen, X.Q. Teo, G.K. Radda, P.T. Lee, Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma, Oncotarget 7 (33) (2016) 53005–53017, http://dx.doi.org/10.18632/oncotarget.10415. 3.M. Marani, A. Paone, A. Fiascarelli, A. Macone, M. Gargano, S. Rinaldo, G.Giardina, V. Pontecorvi, D. Koes, L. McDermott, T. Yang, A. Paiardini, R.Contestabile, F. Cutruzzola, A pyrazolopyran derivative preferentially inhibitsnthe activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells, Oncotarget 7 (4) (2016) 4570–4583, http://dx.doi.org/10.18632/oncotarget.6726