Primary Information
BoMiProt ID	Bomi9028
Protein Name	Serine beta-lactamase-like protein LACTB, mitochondrial
Organism	Bos taurus
Uniprot ID	P83095
Milk Fraction	Whey
Aminoacid Length	556
Molecular Weight	61683
FASTA Sequence	Download
Gene Name	LACTB
Protein Existence Status	reviewed
Secondary Information
Protein Function	mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein.polymerized into stable filaments with a length extending more than a hundred nanometers. through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization.mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells.
PTMs	Acetylation,phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Lysine acetylation of LACTB occurs during starvation indicating that LACTB is modulated by acetyltransferases and deacetylase enzymes.The first serine residue located in the catalytic -SISKmotif of LACTB was phosphorylated under normal conditions suggesting that LACTB is activated by a specific phosphoprotein phosphatase.
Bibliography	Polianskyte Z, Peitsaro N, Dapkunas A, Liobikas J, Soliymani R, Lalowski M, Speer O, Seitsonen J, Butcher S, Cereghetti GM, Linder MD, Merckel M, Thompson J, Eriksson O. LACTB is a filament-forming protein localized in mitochondria. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18960-5. doi: 10.1073/pnas.0906734106. Epub 2009 Oct 26. PMID: 19858488; PMCID: PMC2767363.