Primary Information |
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| BoMiProt ID | Bomi9016 |
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| Protein Name | Semaphorin-3C |
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| Organism | Bos taurus |
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| Uniprot ID | A7MB70 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001094552.1 |
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| Aminoacid Length | 751 |
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| Molecular Weight | 85237 |
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| FASTA Sequence |
Download |
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| Gene Name | SEMA3C |
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| Gene ID | 512660 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Semaphorin 3 C drives epithelial-to-mesenchymal transition.Binds to plexin family members and plays an important role in the regulation of developmental processe. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance. |
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| Significance in milk | role in embryogenesis and neuronal development |
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| PTMs | N linked Glycosylation Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7MB70|SEM3C_BOVIN Semaphorin-3C OS=Bos taurus OX=9913 GN=SEMA3C PE=2 SV=1
MAFQAVCILVGVFVCSTYVKGSPQPQARVYLTFDELRETKTSEYFSLSQYPLDYRILLMD
EDQDRMYVGSKDHILSLNINN*81ISQEPLSVFWPASAIKVEECKMAGKDPTHGCGNFVRVIQ
AFN*123RTHLYVCGSGAFSPVCAYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMIN
EELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKV
YFFFKEKLTDNSRSTKQIHSMIARICPN*268DTGGLRSLVNKWTTFLKARLVCSVTDEDGPET
HFDELEDVFLLEMDNPRTTLVYGIFTTSSSVFKGSAVCVYHFSDIQTVFNGPFAHKEGPN
HQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPVHRRPLI
VRIGTDYKYTKIAVDRVNAADGTYNVLFLGTDRGTVQKVVVLPTN*465SSARSELILEELEVF
KNHAPITTMKISSKKQQLYVSSNEGLAQVSLHRCHIYGSACADCCLARDPYCAWDGHSCS
RFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKN*585N*586TTFLECAPKSPQAS
IKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQDSDQGLYHCIATENSFKQTIAKINFK
VLDSEMVAVVTDKWSPWTWASSVRALPFHPKDIMGAFSHSEMQMINQYCKDTRQQHQQGE
ESQKMRGDYGKLKALINSRKSRNRRNQLPES
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Hui DHF, Tam KJ, Jiao IZF, Ong CJ. Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers. Int J Mol Sci. 2019 Feb 12;20(3):774. doi: 10.3390/ijms20030774. PMID: 30759745; PMCID: PMC6386986. |
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