Primary Information |
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| BoMiProt ID | Bomi8957 |
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| Protein Name | Scavenger receptor cysteine-rich type 1 protein M130/CD_antigen: CD163 |
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| Organism | Bos taurus |
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| Uniprot ID | P85521 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001156885.1 |
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| Aminoacid Length | 1129 |
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| Molecular Weight | 121806 |
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| FASTA Sequence |
Download |
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| Gene Name | CD163/M130 |
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| Gene ID | 533844 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | CD163 is a potential inflammation biomarker and a therapeutic target. |
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| Biochemical Properties | CD163 is a 130-kDa membrane protein with a short cytoplasmic tail, a single transmembrane segment, and a large ectodomain consisting of nine scavenger receptor cysteine rich (SRCR) scavenger receptor class B domains.The SRCR domain is a common 100–110 amino acid domain for molecular interactions and with a determined structural fold of six or seven b-sheets cradling an a-helix. The SRCR class A and class B domains share a similar fold and differ only by the presence of an additional disulfide bond in the class B domains. Whereas SRCR class A domains largely are present as single domains in different mosaic domain proteins, including the scavenger receptor, AI and MARCO. |
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| PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P85521|C163A_BOVIN Scavenger receptor cysteine-rich type 1 protein M130 OS=Bos taurus OX=9913 GN=CD163 PE=1 SV=2
MVLHDNSGSAGFKRCSVHFGPFTLAVVSVLYACLITSALGGTDKELRLVAGQTKCSGRVE
VKVQEEWGTVCNTGWDLAAVSVVCKQLGCPSVIKATGWTN*100SSAGTGRIWMDHVSCRGN*118ES
ALWDCKHEGWGKHN*134CTHQQDVGVTCSDGSDLEMRLMNGGNRCSGRIEIKFQGQWGTVCDD
NFNLDHASVVCKQLGCGSAVSFSGSANFGEGSGPIWFDDLVCHGN*225ESALWNCRHEGWGKH
NCDHAEDAGVICLEGADLSLRLVDGVTKCSGRLEVRFQGEWGTVCDDGWDSDDAAVACQQ
LGCPTAITAVGRVN*314ASEGTGHIWLDSVSCQGHESAVWQCRHHEWGKHYCNHNEDAGVTCS
DGSDLELRLKGGGSRCAGTVEVEIQKLIGKVCDRSWGLKEADVVCKQLGCGSALRTSYQV
YSKIQATNTWLFLNNCNGN*439ETSIWDCKNWQWGGLSCEHYHEAKVTCSAHREPRLVGGDIP
CSGRVEVKHGDTWGTICDSDFSLESASVLCRELECGSVVSILGGAHFGEGNGQIWAEEFQ
CEGN*544ESHLSLCPVAPRLDGTCSHSKDIGVVCSRYTEVRLVGGNTPCEGRVEVKILGTWGP
LCNSHWDMEDAHVLCQQLKCGVAASIPGRAPFGKGSGQPWRHMFHCTGTEQHMGDCPVTA
LGASLCPEGQVASVICSGN*679RSQTLYPCN*688SSSSDPESSVVLEENGVPCIGSGQLRLVNGGG
RCAGRIEVYHEGSWGTICDDSWDLDDAHVVCRQLGCGVAIN*761ATGSAHFGEGSGPIWLDEV
NCNGKEPRISQCRSHGWGRQNCRHKEDAGVICSEFMSLRLISDSSSETCAGRLEVFYNGA
WGSVGKSDMSATTVGVVCRQLGCTDKGSIRPAPSDKVENRYMWVDNVRCPKGPETLWQCP
SSPWKRRLASPSEETWITCADKIRLQEGTTN*931CSGRVEVWHGGSWGTVCDDSWDLNDAQVV
CRQLGCGLALEAGKEAAFGQGTGPIWLNEVKCKGN*995ESSLWDCPARSWGHSDCGHKEDASV
KCSEIAESKGSVKAAGHSSTVALGILGVILLAFLIATLLWIQRRRQRQRLAVSSRGENSV
HEIQYREMNSCLKADDLDLYNSSGLWVLRGSIALGFRLVTAAEAERHST
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (20-42),(1039-1061) |
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| Significance of PTMs | A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This proteolytic cleavage is performed by protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. |
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| Additional Comments | A high CD163 expression in macrophages is a characteristic of tissues responding to inflammation.The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. |
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| Bibliography | 1Kowal K, Silver R, Sławińska E, Bielecki M, Chyczewski L, Kowal-Bielecka O. CD163 and its role in inflammation. Folia Histochem Cytobiol. 2011;49(3):365-74. doi: 10.5603/fhc.2011.0052. PMID: 22038213. 2.Etzerodt A, Moestrup SK. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63. doi: 10.1089/ars.2012.4834. Epub 2012 Oct 19. PMID: 22900885; PMCID: PMC3638564. |
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