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Primary Information | |
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| BoMiProt ID | Bomi8952 |
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1/SERCA1/SR Ca(2+)-ATPase 1/Calcium pump 1/Calcium-transporting ATPase sarcoplasmic reticulum type/ fast twitch skeletal muscle isoform/Endoplasmic reticulum class 1/2 Ca(2+) ATPase |
| Organism | Bos taurus |
| Uniprot ID | Q0VCY0 |
| Milk Fraction | whey |
| Ref Sequence ID | NP_001069235.1 |
| Aminoacid Length | 993 |
| Molecular Weight | 109290 |
| FASTA Sequence | Download |
| Gene Name | ATP2A1 |
| Gene ID | 518117 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | It is an important regulator of striated muscle performance. It catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen |
| Biochemical Properties | It acts as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. |
| PTMs | Phosphorylation and Disulphide bond |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q0VCY0|AT2A1_BOVIN Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Bos taurus OX=9913 GN=ATP2A1 PE=1 SV=1 MEAAHSKTTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVLEQFEDL LVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALK EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILTIKSTTLRVDQSIL TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKAIGIVATTGVGTEIGKIRDQMA ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ MSVCKMFIIDRIDGDLCLLNEFSVTGSTYAPEGEVLKNDKPVRSGQYDGLVELATICALC NDSSLDFNETKGIYEKVGEAT*441ETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMK KEFTLEFSRDRKSMSVYCSPAKSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPV KEKILSVIKEWGTGRDTLRCLALATRDT*568PPKREEMVLDDS*580TKFMEYETDLTFVGVVGMLD PPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEDVADRAYTGREFDDL PLAEQREACRRACCFARVEPTHKSKIVEYLQSFDEITAMTGDGVNDAPALKKAEIGIAMG SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRTPKEPLISGWLFFRYMAIG GYVGAATVGAAAWWFLYAEDGPHVTYSQLTHFMKCSEHSPDFEGVDCEVFEAPQPMTMAL SVLVTIEMCNALNSLSENQSLVRMPPWVNIWLVGSIGLSMSLHFLILYVDPLPMIFKLQA LDLYHWLMVLKISLPVIGLDEILKFVARNYLEG |
| CATH | Matched CATH superfamily 1.20.1110.10 3.40.1110.10 3.40.50.1000 2.70.150.10 1.20.1110.10 3.40.1110.10 3.40.50.1000 2.70.150.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 5TMHs; (60-78),( 85-107),(836-858),(927-949) and (961-979) |
| PDB ID | 3TLM, |
| Bibliography | Sacchetto, R., Bertipaglia, I., Giannetti, S., Cendron, L., Mascarello, F., Damiani, E., Carafoli, E., & Zanotti, G. (2012). Crystal structure of sarcoplasmic reticulum Ca2+-ATPase (SERCA) from bovine muscle. Journal of structural biology, 178(1), 38–44. https://doi.org/10.1016/j.jsb.2012.02.008 |