Primary Information |
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| BoMiProt ID | Bomi8895 |
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| Protein Name | RNA-binding protein with serine-rich domain 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QR16 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095311.1 |
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| Aminoacid Length | 305 |
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| Molecular Weight | 34196 |
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| FASTA Sequence |
Download |
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| Gene Name | RNPS1 |
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| Gene ID | 504506 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | a component of pre-splicing and post-splicing multiprotein complexes, which activates constitutive and alternative splicing.participates in the formation of the spliceosome and activates the pre-mRNA splicing process. |
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| PTMs | ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QR16|RNPS1_BOVIN RNA-binding protein with serine-rich domain 1 OS=Bos taurus OX=9913 GN=RNPS1 PE=2 SV=1
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESS*53EKDRGRD
KTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSS
SGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRS*155PS*157PKPT*161KVHIGRLTRNVTKDHIMEI
FSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLA
PWPRPPPRRFSPPRRMLPPLPMWRRSPPRMRRRSRSPRRRSPARRRSRSPGRRRHRSRSS
SNSSR
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| Predicted Disorder Regions | 1-160, 238-253, 261-305 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | RNPS1 is polyubiquitinated by both K48- and K63-linkages, USP4 exclusively deubiquitinates K63-linked polyubiquitin chains of RNPS1. |
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| Bibliography | Kwon SK, Kim EH, Baek KH. RNPS1 is modulated by ubiquitin-specific protease 4. FEBS Lett. 2017 Jan;591(2):369-381. doi: 10.1002/1873-3468.12531. Epub 2017 Jan 8. PMID: 27990632. |
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