Search by BoMiProt ID - Bomi8894


Primary Information

BoMiProt ID Bomi8894
Protein Name RNA-binding protein 44/RNA-binding motif protein 44
Organism Bos taurus
Uniprot IDE1BC15
Milk FractionWhey,MFGM
Aminoacid Length 1051
Molecular Weight 117960
FASTA Sequence Download
Gene Name RBM44
Protein Existence Status reviewed

Secondary Information

Protein Function Acts as as a novel germ cell intercellular bridge protein.RBM44 migrates from the cytoplasm to the intercellular bridges during meiosis, integrates into the bridge, and then becomes dispersed from the bridges after round spermatids are formed.
Biochemical Properties RBM44 is highly conserved between mouse and human and contains an RNA recognition motif.The RRM of RBM44 might bind to RNAs in the cytoplasm and help to shuttle them through the intercellular bridge, facilitating their dispersion into the interconnected neighboring cells.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|E1BC15|RBM44_BOVIN RNA-binding protein 44 OS=Bos taurus OX=9913 GN=RBM44 PE=3 SV=1 MQATAVVETASNKGYNNNGRNIQKDEPSHHKKENLLSPNGCKEAKLTFLNDYYDSLALEK RANDKEISNIDKIDLLEPSFTMSPDTNIESAHSQSSEFEDNIDYAFLNETYTIHYSESKL KSESLIHLNSELDSEMQKREEVFFDILEHQGDKITDLERIYKISYDDYKKTAEDVQKPDI DEDSQQEYHSAEEQECINNHLSFDQAKTLDIPNLEVLGLRNSGCEVKCVSNLEDSHVKLE SNSSISLDSVDVYGQEDSPSVSKLQNSVTLRAFHEPKYEKCKEQGTSLMLHTVLDEIILR SSHLEHKESESKGFLNPQKALKTKIYTHKVNPQLTESKDSIGNVIVEDKMLQHLDNPGTL PQDKHLETLLQPCKDCQTSSVFDDS*385VIS*388ASGYSHYESLQSTPNPALDVSITLPRSAIRGN QAVEESGSLKVANGNTISKAHFHNMEGPCPKSETDAAGCTVTVDQTVDVSTDFRACFTAS RATSARSSVVSTSSNTEITMMNKKRPSEWQSEKQRSVACNTDWSYIQDTEDPQMAMTKGP TGKSLS*546VDNLKPNGNVLNKDSLELKTFEFTDLKKHSESMLQIQVEKNLPSKCCQQIMQRA IQAESHLLNVHYQLCHRHCSDIYRLVMEDREGLNRNLSSNSTRKELGSALLSVLGDLKVR YMNLKEKINKGIPLEELPPLSIESRLLSAFSTFASRLMKEESHIFSGADSELDNQS*716TRDV GS*722SSLKKTLSQTSLLLDNGHPKQDKSPEEGGLKNGDINVDLSQLKLDDKDCKNYREVSED WFDAKENLTGADFSGIQENQIEQDKGDPKFTLAEIKNVEPLRKDKGYLMHVGGLCPSVSE ADLRSYFQKYEISDISIYDSSPNYRYASLAFKKNSDAKMAVKEMNGIEIKGKSVNVRLVK TPGEYTPLSSKNGNKVSFSNLEKSTSKEMSSPSSVSRLPRTRPRQPGSEQDSEFFPFDQK GVKKNCKQIESTKLLPDTPIQFIPPKTLNLRSFTKIIKRLAELHPEVSRHRDHIIDALQE VRVNHKGFLNGLSINTIVEMTSSVLENSASS
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments RBM44 is expressed most highly in pachytene and secondary spermatocytes, but disappears abruptly in spermatids.Rbm44 null male mice produce somewhat increased sperm, and show enhanced fertility
Bibliography Iwamori T, Lin YN, Ma L, Iwamori N, Matzuk MM. Identification and characterization of RBM44 as a novel intercellular bridge protein. PLoS One. 2011 Feb 25;6(2):e17066. doi: 10.1371/journal.pone.0017066. PMID: 21364893; PMCID: PMC3045441.