Primary Information |
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BoMiProt ID | Bomi8894 |
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Protein Name | RNA-binding protein 44/RNA-binding motif protein 44 |
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Organism | Bos taurus |
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Uniprot ID | E1BC15 |
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Milk Fraction | Whey,MFGM |
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Aminoacid Length | 1051 |
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Molecular Weight | 117960 |
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FASTA Sequence |
Download |
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Gene Name | RBM44 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Acts as as a novel germ cell intercellular bridge protein.RBM44 migrates from the cytoplasm to the intercellular bridges during meiosis, integrates into the bridge, and then becomes dispersed from the bridges after round spermatids are formed. |
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Biochemical Properties | RBM44 is highly conserved between mouse and human and contains an RNA recognition motif.The RRM of RBM44 might bind to RNAs in the cytoplasm and help to shuttle them through the intercellular bridge, facilitating their dispersion into the interconnected neighboring cells. |
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PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BC15|RBM44_BOVIN RNA-binding protein 44 OS=Bos taurus OX=9913 GN=RBM44 PE=3 SV=1
MQATAVVETASNKGYNNNGRNIQKDEPSHHKKENLLSPNGCKEAKLTFLNDYYDSLALEK
RANDKEISNIDKIDLLEPSFTMSPDTNIESAHSQSSEFEDNIDYAFLNETYTIHYSESKL
KSESLIHLNSELDSEMQKREEVFFDILEHQGDKITDLERIYKISYDDYKKTAEDVQKPDI
DEDSQQEYHSAEEQECINNHLSFDQAKTLDIPNLEVLGLRNSGCEVKCVSNLEDSHVKLE
SNSSISLDSVDVYGQEDSPSVSKLQNSVTLRAFHEPKYEKCKEQGTSLMLHTVLDEIILR
SSHLEHKESESKGFLNPQKALKTKIYTHKVNPQLTESKDSIGNVIVEDKMLQHLDNPGTL
PQDKHLETLLQPCKDCQTSSVFDDS*385VIS*388ASGYSHYESLQSTPNPALDVSITLPRSAIRGN
QAVEESGSLKVANGNTISKAHFHNMEGPCPKSETDAAGCTVTVDQTVDVSTDFRACFTAS
RATSARSSVVSTSSNTEITMMNKKRPSEWQSEKQRSVACNTDWSYIQDTEDPQMAMTKGP
TGKSLS*546VDNLKPNGNVLNKDSLELKTFEFTDLKKHSESMLQIQVEKNLPSKCCQQIMQRA
IQAESHLLNVHYQLCHRHCSDIYRLVMEDREGLNRNLSSNSTRKELGSALLSVLGDLKVR
YMNLKEKINKGIPLEELPPLSIESRLLSAFSTFASRLMKEESHIFSGADSELDNQS*716TRDV
GS*722SSLKKTLSQTSLLLDNGHPKQDKSPEEGGLKNGDINVDLSQLKLDDKDCKNYREVSED
WFDAKENLTGADFSGIQENQIEQDKGDPKFTLAEIKNVEPLRKDKGYLMHVGGLCPSVSE
ADLRSYFQKYEISDISIYDSSPNYRYASLAFKKNSDAKMAVKEMNGIEIKGKSVNVRLVK
TPGEYTPLSSKNGNKVSFSNLEKSTSKEMSSPSSVSRLPRTRPRQPGSEQDSEFFPFDQK
GVKKNCKQIESTKLLPDTPIQFIPPKTLNLRSFTKIIKRLAELHPEVSRHRDHIIDALQE
VRVNHKGFLNGLSINTIVEMTSSVLENSASS
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | no TM helices |
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Additional Comments | RBM44 is expressed most highly in pachytene and secondary spermatocytes, but disappears abruptly in spermatids.Rbm44 null male mice produce somewhat increased sperm, and show enhanced fertility |
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Bibliography | Iwamori T, Lin YN, Ma L, Iwamori N, Matzuk MM. Identification and characterization of RBM44 as a novel intercellular bridge protein. PLoS One. 2011 Feb 25;6(2):e17066. doi: 10.1371/journal.pone.0017066. PMID: 21364893; PMCID: PMC3045441. |