Primary Information |
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| BoMiProt ID | Bomi8886 |
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| Protein Name | RNA polymerase II elongation factor ELL3 |
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| Organism | Bos taurus |
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| Uniprot ID | F1MGG3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039591.1 |
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| Aminoacid Length | 395 |
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| Molecular Weight | 44890 |
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| FASTA Sequence |
Download |
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| Gene Name | ELL3 |
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| Gene ID | 512648 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Ell3, a member of the Ell (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II elongation factors, occupies enhancers in embryonic stem cells. |
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| Biochemical Properties | ELL3, a novel RNA polymerase II elongation factor approximately 50% similar to both ELL and ELL2.Ell3's association with enhancers is required for setting up proper Pol II occupancy at the promoter-proximal regions of developmentally regulated genes and for the recruitment of the super elongation complex (SEC) to these loci following differentiation signals. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-5, 121-303, 339-342 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | ELL3 is a testis-specific RNA polymerase II elongation factor. |
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| Bibliography | 1.Lin C, Garruss AS, Luo Z, Guo F, Shilatifard A. The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell. 2013 Jan 17;152(1-2):144-56. doi: 10.1016/j.cell.2012.12.015. Epub 2012 Dec 27. PMID: 23273992; PMCID: PMC3556173. 2.Miller T, Williams K, Johnstone RW, Shilatifard A. Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3. J Biol Chem. 2000 Oct 13;275(41):32052-6. doi: 10.1074/jbc.M005175200. PMID: 10882741. |
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