Primary Information |
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| BoMiProt ID | Bomi8808 |
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| Protein Name | Ribosome biogenesis regulatory protein homolog |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KIH4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001068949.1 |
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| Aminoacid Length | 365 |
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| Molecular Weight | 41427 |
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| FASTA Sequence |
Download |
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| Gene Name | RRS1 |
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| Gene ID | 510956 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ribosome biogenesis.RRS1 interacts with RPF2 to form a complex that regulates the maturation of the 60S ribosomal subunit |
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| PTMs | Acetylation, Citrullination, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KIH4|RRS1_BOVIN Ribosome biogenesis regulatory protein homolog OS=Bos taurus OX=9913 GN=RRS1 PE=2 SV=1
MEGQS*5VEELLAKAERDEAEKLQRITVLKELELEFDLGNLLASDRNPPTGLRHAGPTQEAE
LRALARDNTQLLINQLWQLPTERVEEALVARLPEPSTRLPREKPVPRPRPLTRWQQFARL
KGIRPKKKTNLVWDEVSGRWRRRWGYQRARDDTKEWLIEVPGNADPMEDQFAKRIQAKKE
RVAKNELNRLRNLARAHKMQLPSAAGMHPTGHQSKEELGRAMQVAKVSTASVGRFQERLP
KEKAPRGSGKKRKFQPLFGDFAAERKSQLEMLRVMNSKKPQMDITRATNKQMREEDQEEA
AKRRKMSQKGKRKGGRQGPGSKRKGGTPSQGGKRKGGLGGKMNSGPPGLSGKRKGGQHQG
GKRRK |
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| Predicted Disorder Regions | 1-20, 38-65, 87-365 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | RRS1 functions as an oncogene in Retinoblastoma via activating the AKT/mTOR signaling pathway. |
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| Bibliography | Yan X, Wu S, Liu Q, Zhang J. RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway. Biomed Res Int. 2020 Nov 2;2020:2420437. doi: 10.1155/2020/2420437. PMID: 33204686; PMCID: PMC7652605. |
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