Primary Information |
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| BoMiProt ID | Bomi8776 |
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| Protein Name | Rho-related GTP-binding protein RhoB |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBW5 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001071390.1 |
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| Aminoacid Length | 196 |
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| Molecular Weight | 22123 |
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| FASTA Sequence |
Download |
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| Gene Name | RHOB |
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| Gene ID | 515118 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | ureter |
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| Protein Function | Normally it mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Ras and Rho-related GTP-binding proteins can activate MAPK or JNK in a variety of cell lines. |
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| PTMs | Lipoylation, Methylation, Palmitoylation, Phosphorylation at Tyr, Prenylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3ZBW5|RHOB_BOVIN Rho-related GTP-binding protein RhoB OS=Bos taurus OX=9913 GN=RHOB PE=2 SV=1
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD
LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAY*154DYLECSAKTKEGVREVFETATRAALQ
KRYGSQNGCINCCKVL
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome |
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| Bibliography | 1.Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, Gutkind JS. The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J Biol Chem. 1996 Oct 18;271(42):25731-4. doi: 10.1074/jbc.271.42.25731. PMID: 8824197. |
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