Search by BoMiProt ID - Bomi8774

Primary Information

BoMiProt ID Bomi8774
Protein Name Rho-related GTP-binding protein Rho6/Rho family GTPase 1/Rnd1
Organism Bos taurus
Uniprot IDQ2HJ68
Milk FractionWhey
Ref Sequence ID NP_001039481.1
Aminoacid Length 232
Molecular Weight 26029
FASTA Sequence Download
Gene Name RND1/RHO6
Gene ID 508869
Protein Existence Status reviewed

Secondary Information

Protein Function Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy.RND1 is involved in oncogenesis and response to cancer therapeutics.
Biochemical Properties RND1 shares 41% identity with RHOA protein, RND proteins differ from other Rho GTPases by several features. They contain an extension of 30 amino acids at the C-terminal and RND1 and RND3 proteins possess 8 and 18 additional amino acids, respectively, at the N-terminal. At the N-terminal, RND1 and RND3 (but not RND2) contain a KERRA (Lys-Glu-Arg-Arg-Ala) sequence that mediates their targeting to lipid rafts, and so their localization at the plasma membrane.
PTMs Lipoprotein formation, Methylation at Cys, Prenylation at Cys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-10, 192-208, 213-232
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs When phosphorylation occurs near the CAAX box, it alters the localization and function of Rho GTPases. The binding of the phosphorylated form of RND1 on S228, close to the CAAX box, to 14-3-3 protein induces the translocation of RND1 from the plasma membrane to the cytoplasm and reverses the typical RND1 rounded phenotype.
Additional Comments Low expression of RND1 is associated with a bad prognosis for the patients. RND1 expression is induced by anticancer agents and modulates their response. 
Bibliography 1.Mouly L, Gilhodes J, Lemarié A, Cohen-Jonathan Moyal E, Toulas C, Favre G, Sordet O, Monferran S. The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis. Int J Mol Sci. 2019 Jul 24;20(15):3612. doi: 10.3390/ijms20153612. PMID: 31344837; PMCID: PMC6696182. 2.A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P J Cell Biol. 1998 Apr 6; 141(1):187-97. 3.Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation. Oinuma I, Kawada K, Tsukagoshi K, Negishi M Mol Biol Cell. 2012 Apr; 23(8):1593-604. 4.14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Riou P, Kjær S, Garg R, Purkiss A, George R, Cain RJ, Bineva G, Reymond N, McColl B, Thompson AJ, O'Reilly N, McDonald NQ, Parker PJ, Ridley AJ.