Primary Information |
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| BoMiProt ID | Bomi8744 |
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| Protein Name | Rho family-interacting cell polarization regulator 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3B7M3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030502.1 |
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| Aminoacid Length | 1016 |
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| Molecular Weight | 111934 |
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| FASTA Sequence |
Download |
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| Gene Name | RIPOR2/FAM65B |
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| Gene ID | 539635 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | role in morphogenesis of the hair cell bundle.an inhibitor of the small GTPase RHOA |
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| Biochemical Properties | Fam65b protein contains BAR domains, that promote membrane anchoring. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3B7M3|RIPR2_BOVIN Rho family-interacting cell polarization regulator 2 OS=Bos taurus OX=9913 GN=RIPOR2 PE=2 SV=1
MLVGSQSFSPGGPNGIIRSQS*21FAGFSGLQERRSRCNS*37FIENSSAVKKPQAKLKKMHNLGH
KNSSPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTTQLKDMRRNSRLGVLYDLDK
QIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLAEIN
RSYKEYTENMCAIEAELEKQLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGRI
EVNGKQSWDGEEMVFLPLIVGFISIKVTELKGLATHLLVGSVTCETKELFAARPQVVAVD
INDLGTIKLNLEITWYPFDVEDMTPSSGAGNKVAALQRRMS*341MYSQGTPETPTFKDHSFFS
NLPDDIFENGKAAEEKMPLSLSFSDLPNGDCTLAPGPADSLPGACAANPEITITSTELPP
GSQSSQNEGLKDSSSASCSSSSREGSEPRPHPEGETQGLGKPEGCPVATGARPERLFLQK
GVAEALLQEALLQEPSELKPVELDTFEGNITKQLVKRLTS*520AEVPAATERLLS*532EGSISAES
EGCRSFLDGSLEDAFNGLFLALEPHKEQYKEFQDLNQEVMHLDDILKCKPAVSRSRSSSL
SLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKNSYRSVHPEARGHL
SEALTEDTGVGTSVAGSPLPLTTGNESLDLTIIRHLQYCTQLVQQIVLSSKTPFVASNLL
EKLSRQIQVMEKLSAVSDENIGNISSVIEAIPEFHKKLSLLSFWTKCCTPIGVYHSSADR
VIKQLEASFARTVNRDYPGLADPVFHTLVSQILDRAEPLLPASLSSEVITVFQYYSYFTS
HGVSDLESYLNQLAKQVSVVQTLQSLRDEKLLQAVSDLAPGSFPAPQEEVLRTLALLLTG
EDSGASEAVTLYLTAASRSEHFREKALLYYCEALTKTDFRLQKAACLALKSLKATESIKM
LVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRLASEVATAF
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| Predicted Disorder Regions | 42-66, 371-472, 639-673 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | chemokine stimulation phosphorylates Fam65b in T lymphocytes via PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization.This post-translational modification decreases the affinity of Fam65b for RhoA and favors Fam65b shuttling from the plasma membrane to the cytosol. |
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| Bibliography | Diaz-Horta O, Abad C, Cengiz FB, Bademci G, Blackwelder P, Walz K, Tekin M. Ripor2 is involved in auditory hair cell stereociliary bundle structure and orientation. J Mol Med (Berl). 2018 Nov;96(11):1227-1238. doi: 10.1007/s00109-018-1694-x. Epub 2018 Oct 3. PMID: 30280293; PMCID: PMC6238639. |
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