Primary Information
BoMiProt ID	Bomi8740
Protein Name	Retinol-binding protein 3/Interphotoreceptor retinoid-binding protein/Interstitial retinol-binding protein/Protein 7S/IRBP
Organism	Bos taurus
Uniprot ID	P12661
Milk Fraction	Whey
Ref Sequence ID	NP_776589.1
Aminoacid Length	1286
Molecular Weight	139698
FASTA Sequence	Download
Gene Name	RBP3
Gene ID	281443
Protein Existence Status	reviewed
Secondary Information
Protein Function	RBP3 may have a role in protection against the progression of diabetic retinotherapy due to hyperglycemia by inhibiting glucose uptake via GLUT1 and decreasing the expression of inflammatory cytokines and VEGF.
Biochemical Properties	Only all-trans-retinol, not retinal or retinoic acid, competes for binding. The binding of radioactive retinol is reversible.
PTMs	Glycosylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|P12661|RET3_BOVIN Retinol-binding protein 3 OS=Bos taurus OX=9913 GN=RBP3 PE=1 SV=1 MVRKWALLLPMLLCGLTGPAHLFQPSLVLEMAQVLLDNYCFPENLMGMQGAIEQAIKSQE ILSISDPQTLAHVLTAGVQSSLNDPRLVISYEPSTLEAPPRAPAVTN*107LTLEEIIAGLQDG LRHEILEGNVGYLRVDDIPGQEVMSKLRSFLVANVWRKLVN*161TSALVLDLRHCTGGHVSGI PYVISYLHPGSTVSHVDTVYDRPSN*205TTTEIWTLPEALGEKYSADKDVVVLTSSRTGGVAE DIAYILKQMRRAIVVGERTVGGALNLQKLRVGQSDFFLTVPVSRSLGPLGEGSQTWEGSG VLPCVGTPAEQALEKALAVLMLRRALPGVIQRLQEALREYYTLVDRVPALLSHLAAMDLS SVVSEDDLVTKLNAGLQAVSEDPRLQVQVVRPKEASSGPEEEAEEPPEAVPEVPEDEAVR RALVDSVFQVSVLPGNVGYLRFDSFADASVLEVLGPYILHQVWEPLQDTEHLIMDLRQNP GGPSSAVPLLLSYFQSPDASPVRLFSTYDRRTN*513ITREHFSQTELLGRPYGTQRGVYLLTS HRTATAAEELAFLMQSLGWATLVGEITAGSLLHTHTVSLLETPEGGLALTVPVLTFIDNH GECWLGGGVVPDAIVLAEEALDRAQEVLEFHRSLGELVEGTGRLLEAHYARPEVVGQMGA LLRAKLAQGAYRTAVDLESLASQLTADLQEMSGDHRLLVFHSPGEMVAEEAPPPPPVVPS PEELSYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVQLVWQKLVDTAALVVDL RYNPGSYSTAVPLLCSYFFEAEPRRHLYSVFDRATSRVTEVWTLPHVTGQRYGSHKDLYV LVSHTSGSAAEAFAHTMQDLQRATIIGEPTAGGALSVGIYQVGSSALYASMPTQMAMSAS TGEAWDLAGVEPDITVPMSVALSTARDIVTLRAKVPTVLQTAGKLVADNYASPELGVKMA AELSGLQSRYARVTSEAALAELLQADLQVLSGDPHLKTAHIPEDAKDRIPGIVPMQIPSP EVFEDLIKFSFHTNVLEGNVGYLRFDMFGDCELLTQVSELLVEHVWKKIVHTDALIVDMR FNIGGPTSSISALCSYFFDEGPPILLDKIYNRPN*1114NSVSELWTLSQLEGERYGSKKSMVIL TSTLTAGAAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTDLYLTIPTARSVGAAD GSSWEGVGVVPDVAVPAEAALTRAQEMLQHTPLRARRSPRLHGRRKGHHRQSQGRAGSLG RNQGVVRPEVLTEAPSGQKRGLLQCG
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	The RBP3-related disease should be considered in children with high myopia and retinal dystrophy, particularly when there are no significant fundus changes.
Bibliography	1.Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 Jul 3;11(499):eaau6627. doi: 10.1126/scitranslmed.aau6627. PMID: 31270273; PMCID: PMC7132633. 2.Arno G, Hull S, Robson AG, Holder GE, Cheetham ME, Webster AR, Plagnol V, Moore AT. Lack of Interphotoreceptor Retinoid Binding Protein Caused by Homozygous Mutation of RBP3 Is Associated With High Myopia and Retinal Dystrophy. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2358-65. doi: 10.1167/iovs.15-16520. PMID: 25766589.