Primary Information |
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| BoMiProt ID | Bomi8736 |
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| Protein Name | Retinol dehydrogenase 12/Double substrate specificity short-chain dehydrogenase/reductase 2 |
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| Organism | Bos taurus |
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| Uniprot ID | P59837 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_899207.1 |
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| Aminoacid Length | 316 |
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| Molecular Weight | 35171 |
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| FASTA Sequence |
Download |
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| Gene Name | RDH12/DSSDR2 |
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| Gene ID | 369021 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Retina |
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| Protein Function | NADPH-dependent retinal reductase, which is expressed in the inner segments of the photoreceptors. It functions as part of the visual cycle, which is a series of enzymatic reactions required for the regeneration of the visual pigment, and also participate in detoxification of lipid peroxidation products. can protect cells from nonanal induced toxity. |
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| Biochemical Properties | A member of the short chain dehydrogenases/reductases (SDR) family of enzymes.Contains highly conserved Rossman fold, which is composed of a central β-sheet flanked by 3–4 α-helices, forming the cofactor binding site. The SDRs have two conserved domains: the cofactor binding site (GXXXGXG) and the catalytic site (YXXXK).Purified RDH12 displays a 2000 fold higher affinity for NADP+ and NADPH than for NAD+ and NADH, and has a greater affinity for retinaldehydes. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (3-21) |
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| Additional Comments | Leber Congenital amaurosis(LCA) is due to Mutations in RDH12. |
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| Bibliography | 1.Sarkar H, Moosajee M. Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. Exp Eye Res. 2019 Nov;188:107793. doi: 10.1016/j.exer.2019.107793. Epub 2019 Sep 7. PMID: 31505163. |
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