Search by BoMiProt ID - Bomi8736

Primary Information

BoMiProt ID Bomi8736
Protein Name Retinol dehydrogenase 12/Double substrate specificity short-chain dehydrogenase/reductase 2
Organism Bos taurus
Uniprot IDP59837
Milk FractionWhey
Ref Sequence ID NP_899207.1
Aminoacid Length 316
Molecular Weight 35171
FASTA Sequence Download
Gene Name RDH12/DSSDR2
Gene ID 369021
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Retina
Protein Function NADPH-dependent retinal reductase, which is expressed in the inner segments of the photoreceptors. It functions as part of the visual cycle, which is a series of enzymatic reactions required for the regeneration of the visual pigment, and also participate in detoxification of lipid peroxidation products. can protect cells from nonanal induced toxity.
Biochemical Properties A member of the short chain dehydrogenases/reductases (SDR) family of enzymes.Contains highly conserved Rossman fold, which is composed of a central β-sheet flanked by 3–4 α-helices, forming the cofactor binding site. The SDRs have two conserved domains: the cofactor binding site (GXXXGXG) and the catalytic site (YXXXK).Purified RDH12 displays a 2000 fold higher affinity for NADP+ and NADPH than for NAD+ and NADH, and has a greater affinity for retinaldehydes.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (3-21)
Additional Comments Leber Congenital amaurosis(LCA) is due to Mutations in RDH12.
Bibliography 1.Sarkar H, Moosajee M. Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. Exp Eye Res. 2019 Nov;188:107793. doi: 10.1016/j.exer.2019.107793. Epub 2019 Sep 7. PMID: 31505163.