Primary Information |
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| BoMiProt ID | Bomi8725 |
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| Protein Name | Retinal guanylyl cyclase 1/Guanylate cyclase 2D, retinal/Guanylate cyclase E/Rod outer segment membrane guanylate cyclase |
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| Organism | Bos taurus |
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| Uniprot ID | P55203 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 1110 |
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| Molecular Weight | 120369 |
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| FASTA Sequence |
Download |
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| Gene Name | GUCY2D |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | It facilitates the cGMP synthesis in photoreceptors of eyes i.e. rods and cones. It also has crucial role in phototransduction and it does so by mediating replineshment of cGMP. |
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| Significance in milk | phototransduction |
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| PTMs | Disulphide bond, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P55203|GUC2D_BOVIN Retinal guanylyl cyclase 1 OS=Bos taurus OX=9913 GN=GUCY2D PE=1 SV=1
MTACTFLAGGLRDPGLCGPTRWAPSPPGLPPIPPRPRLRLRPPLLLLLLLPRSVLSAVFT
VGVLGPWACDPIFARARPDLAARLAASRLNHAAALEGGPRFEVALLPEPCRTPGSLGAVS
SALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPVVTPAADALYAL
LRAFRWAHVALVTAPQDLWVEAGHALSTALRARGLPVALVTSMEPSDLSGAREALRRVQD
GPRVRAVIMVMHSVLLGGEEQRCLLEAAEELGLADGSLVFLPFDTLHYALSPGPDALAVL
AN*302SSQLRKAHDAVLTLTRHCPLGGSVRDSLRRAQEHRELPLDLNLQQVSPLFGTIYDSVF
LLAGGVARARVAAGGGWVSGAAVARHIRDARVPGFCGALGGAEEPSFVLLDTDATGDQLF
ATYVLDPTQGFFHSAGTPVHFPKGGRGPGPDPSCWFDPDTICNGGVEPSVVFIGFLLVVG
MGLAGAFLAHYCRHRLLHIQMVSGPNKIILTLDDITFLHPHGGNSRKVAQGSRTSLAARS
ISDVRSIHSQLPDYTNIGLYEGDWVWLKKFPGDRHIAIRPATKMAFSKIRELRHENVALY
LGLFLAGGAGGPAAPGEGVLAVVSEHCARGSLQDLLAQRDIKLDWMFKSSLLLDLIKGIR
YLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLR
DPVLERRGTLAGDVFSLGIIMQEVVCRSAPYAMLELTPEEVVKRVQSPPPLCRPSVSIDQ
APMECIQLMKQCWAEQPELRPSMDRTFELFKSINKGRKMNIIDSMLRMLEQYSSNLEDLI
RERTEELELEKQKTDRLLTQMLPPSVAEALKMGTPVEPEYFEEVTLYFSDIVGFTTISAM
SEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGHRHAAEIANMALD
ILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASAMESTGLP
YRIHVNRSTVQILSALNEGFLTEVRGRTELKGKGAEETYWLVGRRGFNKPIPKPPDLQPG
ASNHGISLHEIPPDRRQKLEKARPGQFSGK
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| Predicted Disorder Regions | (22-36), (1100-1110) |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (470-492),(596-614) |
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| Significance of PTMs | N-linked glycosylation of asparagine at 302 position. |
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| Bibliography | Goraczniak, R. M., Duda, T., Sitaramayya, A., & Sharma, R. K. (1994). Structural and functional characterization of the rod outer segment membrane guanylate cyclase. The Biochemical journal, 302 ( Pt 2)(Pt 2), 455–461. https://doi.org/10.1042/bj3020455 |
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