Search by BoMiProt ID - Bomi8691

Primary Information

BoMiProt ID Bomi8691
Protein Name Regulator of G-protein signaling 9
Organism Bos taurus
Uniprot IDO46469
Milk FractionWhey
Ref Sequence ID NP_776595.1
Aminoacid Length 484
Molecular Weight 56680
FASTA Sequence Download
Gene Name RGS9
Gene ID 281453
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells highly enriched in the striatum, a brain region that mediates motivation, movement and reward responses.
Protein Function Regulator of GPCR signalling.inhibits GPCR signalling by increasing GTPases activity of G protein driving them into their inactive GDP-bound form.RGS9‐1 in photoreceptors exists as a constitutive dimer with Gb5L and the entire RGS9-1-Gβ5 complex is tethered on the membrane surface by the transmembrane anchor R9AP.
Biochemical Properties DEP domain is necessary for binding to transmembrane anchor protein R9AP. GGL domain is necessary for binding to Gβ5 protein.
PTMs phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Regulator of G-protein signaling, RGS
Superfamily : Regulator of G-protein signaling, RGS
Family : Regulator of G-protein signaling, RGS
Domain Name : 1FQI A:283-420

CATH Matched CATH superfamily
Predicted Disorder Regions 420-484
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs NXS consensus sequence of RGS9 for N-glycosylation at position 299–301 is conserved across all mammalian species.
Additional Comments lack of RGS9‐1 function in humans lead to the visual disorder bradyopsia (slow vision)
Bibliography Martemyanov KA, Arshavsky VY. Biology and functions of the RGS9 isoforms. Prog Mol Biol Transl Sci. 2009;86:205-27. doi: 10.1016/S1877-1173(09)86007-9. Epub 2009 Oct 7. PMID: 20374717. 2.Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15;240(1):23-34. doi: 10.1016/s0378-1119(99)00393-5. PMID: 10564809.