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Primary Information | |
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| BoMiProt ID | Bomi8691 |
| Protein Name | Regulator of G-protein signaling 9 |
| Organism | Bos taurus |
| Uniprot ID | O46469 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776595.1 |
| Aminoacid Length | 484 |
| Molecular Weight | 56680 |
| FASTA Sequence | Download |
| Gene Name | RGS9 |
| Gene ID | 281453 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | highly enriched in the striatum, a brain region that mediates motivation, movement and reward responses. |
| Protein Function | Regulator of GPCR signalling.inhibits GPCR signalling by increasing GTPases activity of G protein driving them into their inactive GDP-bound form.RGS9‐1 in photoreceptors exists as a constitutive dimer with Gb5L and the entire RGS9-1-Gβ5 complex is tethered on the membrane surface by the transmembrane anchor R9AP. |
| Biochemical Properties | DEP domain is necessary for binding to transmembrane anchor protein R9AP. GGL domain is necessary for binding to Gβ5 protein. |
| PTMs | phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : All alpha proteins Fold : Regulator of G-protein signaling, RGS Superfamily : Regulator of G-protein signaling, RGS Family : Regulator of G-protein signaling, RGS Domain Name : 1FQI A:283-420 |
| CATH | Matched CATH superfamily 1.10.167.10 1.10.196.10 |
| Predicted Disorder Regions | 420-484 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | NXS consensus sequence of RGS9 for N-glycosylation at position 299–301 is conserved across all mammalian species. |
| PDB ID | 1FQI,1FQJ,1FQK, |
| Additional Comments | lack of RGS9‐1 function in humans lead to the visual disorder bradyopsia (slow vision) |
| Bibliography | Martemyanov KA, Arshavsky VY. Biology and functions of the RGS9 isoforms. Prog Mol Biol Transl Sci. 2009;86:205-27. doi: 10.1016/S1877-1173(09)86007-9. Epub 2009 Oct 7. PMID: 20374717. 2.Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15;240(1):23-34. doi: 10.1016/s0378-1119(99)00393-5. PMID: 10564809. |