Primary Information |
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| BoMiProt ID | Bomi8685 |
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| Protein Name | Recombining binding protein suppressor of hairless |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SZ41 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070469.1 |
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| Aminoacid Length | 487 |
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| Molecular Weight | 54341 |
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| FASTA Sequence |
Download |
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| Gene Name | RBPJ |
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| Gene ID | 767928 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | RBPJ is a key transcription factor downstream of Notch receptor activation |
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| Biochemical Properties | Recombination signal-binding protein Jκ (RBPJ) is a DNA-binding protein from CSL family of transcription factors [12]. RBPJ recognizes a consensus sequence C(T)GTGGGAA on RBPJ-binding sites from a number of factors [12]. Importantly, RBPJ also mediates signals from Notch receptors |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-18, 77-80, 152-162, 435-487 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | e downregulation of RBPJ expression resulted in a significant reduction of cell growth in transduced prostate cancer cells, confirmed by cell cycle analyses showing that knockdown of RBPJ decreased S-phase proliferating cells. |
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| Bibliography | Xue L, Li H, Chen Q, Wang Z, Zhang P, Chen H, Wang Z, Chong T. Inhibition of Recombining Binding Protein Suppressor of Hairless (RBPJ) Impairs the Growth of Prostate Cancer. Cell Physiol Biochem. 2015;36(5):1982-90. doi: 10.1159/000430166. Epub 2015 Jul 17. PMID: 26202358. |
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