Search by BoMiProt ID - Bomi8634


Primary Information

BoMiProt ID Bomi8634
Protein Name Ras GTPase-activating protein 3
Organism Bos taurus
Uniprot IDQ28013
Milk FractionExosomes
Aminoacid Length 834
Molecular Weight 95386
FASTA Sequence Download
Gene Name RASA3
Protein Existence Status Reviewed

Secondary Information

Protein Function RASA3 (or GTPase Activating Protein III, R-Ras GTPase-activating protein, GAP1(IP4BP)) is a GTPase activating protein of the GAP1 subfamily which targets Ras and Rap1. 
Biochemical Properties The RASA3 protein structure is identical in man and mouse: 2 C2 domains, C2A and C2B, at the N-terminal end of the protein, a central GTPase activating protein (GAP) catalytic domain and a carboxy-terminal pleckstrin homology (PH) domain followed by a Bruton tyrosine kinase (Btk) motif, named the PH/Btk domain. Interestingly, the RASA3 central catalytic domain contains a GAP consensus sequence, F-L-R-X3-P-A-X3-P, which is active on both Ras and Rap1, but not on members of the Rab, Rac or Rho family
PTMs N-acetylation at Ala,Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q28013|RASA3_BOVIN Ras GTPase-activating protein 3 OS=Bos taurus OX=9913 GN=RASA3 PE=2 SV=1 MAVEEEGLRVFQSVKIKIGEAKNLPTYPGPNKMRDCYCTVNLDQEEVFRTKVVEKSLCPF YGEDFY*66CEIPRSFRHLS*77FYIFDRDVFRRDSIIGKVAIKKEDLQKYHNRDT*110WFQLQHVDAD SEVQGKVHLELRLSEVITDSGVVCHKLATRILECQGLPIVNGQCDPYATVTLAGPCRSEA KKTKVKKKTNNPQFDEVFYFEVTRPCSYSRKSHFDFEDEDVDKLEIRVDLWNASNLKFGD EFLGELRVPLKVLRQSSPHEAWYFLQPRDNGSKSLKPGDLGSLRLNVVYTEDHVFSSDYY SPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAIPLVRLFLHYGRVVPFISAIASAEV RRTQDPNTIFRGNSLTSKCIDETMKLAGMQYLHVTLKPTIEEICQSHKSCEIDPVRLKDG ESLESNMENLRQFVDRVFSVITKSGVSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSS FIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLVSKTIQTLGSLSKSKSASFKESYMAA FYEFFNEQKYADAVKNFLDLISSSGRRDPKSVQQPILLKEGFMIKRAQGRKRFGMKNFKK RWFRLTNHEFTYQKSKGDPPLYSIPIENILAVEPLEEESFKMKNMFQVIQPERALYIQAN NCVEAKAWIDILTKVSQCNQKRLAVYHPSAYLNGHWLCCRASSDTAAGCSPCTGGLPANI QLDIDGDRETERIYSLSSSYMSKLETMQEACGSRSVYDGPEQEEYSTFIIDDPQETYKTL KQVVAGVGALEQEHAQYKRDKFRRTKYGS*809QEHPIGDKSFQSYIRQQSETPAHS*833M
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Schurmans S, Polizzi S, Scoumanne A, Sayyed S, Molina-Ortiz P. The Ras/Rap GTPase activating protein RASA3: from gene structure to in vivo functions. Adv Biol Regul. 2015 Jan;57:153-61. doi: 10.1016/j.jbior.2014.09.006. Epub 2014 Sep 28. PMID: 25294679. 2.P.J. Cullen, J.J. Hsuan, A.J. Letcher, T.R. Jackson, A.P. Dawson, R.F. Irvine.Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family.Nature, 376 (1995), pp. 527-530. 3.M. Fukuda, K. Mikoshiba.The function of inositol high polyphosphate binding proteins.BioEssay, 19 (2006), pp. 593-603.