Primary Information |
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| BoMiProt ID | Bomi8621 |
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| Protein Name | Ran-binding protein 10/RanBP10 |
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| Organism | Bos taurus |
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| Uniprot ID | A3KMV8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091594.1 |
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| Aminoacid Length | 620 |
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| Molecular Weight | 67249 |
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| FASTA Sequence |
Download |
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| Gene Name | RANBP10 |
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| Gene ID | 519736 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. |
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| PTMs | Acetylation, phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A3KMV8|RBP10_BOVIN Ran-binding protein 10 OS=Bos taurus OX=9913 GN=RANBP10 PE=2 SV=1
MAAATADPGAGSPQVGDSSGGATGCGLPSPGEQELSRRLQRLYPAVNQHETPLPRSWSPK
DKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGI
GLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTC
FYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGT
VHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQK
LVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDS*361Y*362PGS*365PS*367LS*369PRHGPTSSHTHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSS*422PSSVNYSESNSTDSTKSQPHSSTSNQETS*451DS*453EMEMEAEHYPNGVLESMSTRIVNGAYKHEDLQTDESSMDDGHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKDLAHTEMLQ
DAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLR
LMARAGLGSCSFARVDDYLH
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| Predicted Disorder Regions | 1-29, 44-58, 77-89, 357-478, |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Hou, J., Liu, Y., Huang, P., Wang, Y., Pei, D., Tan, R., Zhang, Y., & Cui, H. (2021). RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway. Cell death & disease, 12(11), 967. https://doi.org/10.1038/s41419-021-04207-4 |
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