Primary Information |
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| BoMiProt ID | Bomi8601 |
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| Protein Name | Radial spoke head protein 3 homolog/A-kinase anchor protein RSPH3/Radial spoke head-like protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A8E4N3 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001103269.1 |
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| Aminoacid Length | 606 |
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| Molecular Weight | 68700 |
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| FASTA Sequence |
Download |
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| Gene Name | RSPH3/RSHL2 |
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| Gene ID | 533135 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Members of the heat-shock protein (HSP)40 regulate the protein folding activity of HSP70 proteins and help the functional specialization of this molecular chaperone system in various types of cellular events.Radial spokes are structurally conserved, macromolecular complexes that are essential for the motility of 9 + 2 motile cilia. |
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| PTMs | Phosphorylation at Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A8E4N3|RSPH3_BOVIN Radial spoke head protein 3 homolog OS=Bos taurus OX=9913 GN=RSPH3 PE=2 SV=1
MARSEARRQAREKRPRAVPEERALRERRQPRPRREPLESGAGDHRRPPQASAGAAGHASF
MRRLVDQEDAGGQSQEPEVLGRTGNLPRKPASRNSPEAPPLDGTLGCWATGAGAAGGFGG
AQNRACVAPTSCPGNLPARPLPFLPPLLASRNPCPWHYVHLSGSHDTLVPTCFEAKLHQK
GSGPTPSATSTLAERASPAMATYTYTSRPRALPCQRRRYRDDLMQQPEEPVHYGNIMYDR
RVIRGNTYALQSVPLPGQPDPVEIQRQQQARRRAFARKQAQEQLRPRTPEPVEGRKHVDV
QTELYLEEIADRIVEVDMECQTDAFLDKPPT*331PLFIPAKTGKDVATEILEGELFDFDLEVK
PMLEVLVGKTIEQSLLEVMEEEELANLRASQYAYEELRNIELAEVQRLEEQERRHREEKE
RRKQQQWQVVHKHNETSQKIAARAFAQRYLADLLPSVFDSLRDGGYFYDPVERDIEIGFL
PWLMNEVDKTMESSMVGRTVLDMLIREVVERRLNLYEQKEGRHASVRPENGLGGPGGTRE
PLVGFESQDQGASQAQRPLPDRDSLQRTPYDARYAERVSSQERRLAEENDELTEMRKSSK
REELSQ
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| Predicted Disorder Regions | 1-18, 70-84, 121-131, 228-241, 266-290, 544-581 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | In Chlamydomonas species, mutations in radial spoke proteins result in ciliary motility defects. |
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| Bibliography | 1.Han X, Xie H, Wang Y, Zhao C. Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB J. 2018 Jul;32(7):3984-3992. doi: 10.1096/fj.201701359R. Epub 2018 Feb 22. PMID: 29475374. 2.Satouh Y, Padma P, Toda T, Satoh N, Ide H, Inaba K. Molecular characterization of radial spoke subcomplex containing radial spoke protein 3 and heat shock protein 40 in sperm flagella of the ascidian Ciona intestinalis. Mol Biol Cell. 2005 Feb;16(2):626-36. doi: 10.1091/mbc.e04-09-0784. Epub 2004 Nov 24. PMID: 15563603; PMCID: PMC545899. |
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