Primary Information |
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| BoMiProt ID | Bomi8560 |
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| Protein Name | Quinone oxidoreductase-like protein 1/Quinone oxidoreductase homolog 1/Zeta-crystallin homolog |
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| Organism | Bos taurus |
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| Uniprot ID | Q59A28 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030209.2 |
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| Aminoacid Length | 349 |
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| Molecular Weight | 38812 |
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| FASTA Sequence |
Download |
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| Gene Name | CRYZL1 |
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| Gene ID | 506426 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | zeta-Crystallin, a major cytosolic protein of guinea pig lens, has been characterized as an NADPH:quinone oxidoreductase |
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| Biochemical Properties | A bovine lens homolog with 83% sequence identity was found to have very different functional characteristics. While the bovine lens zeta-crystallin exhibits similar physicochemical properties, such as molecular weight, hydropathy profile, and predicted secondary structure, and exhibits strong immunological cross-reactivity with the guinea pig and human lens zeta-crystallins, it shows minimal quinone oxidoreductase activity. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | loss of a functional residue accounts for the lowered catalytic activity of the bovine protein, Tyr 52 of the E. coli enzyme, and the equivalent Tyr present in all known mammalian forms except the bovine, is the likely candidate. In the bovine form this tyrosine is replaced by histidine. |
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| Bibliography | 1.Rao PV, Gonzalez P, Persson B, Jörnvall H, Garland D, Zigler JS Jr. Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. Biochemistry. 1997 May 6;36(18):5353-62. doi: 10.1021/bi9622985. PMID: 9154917. |
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