Primary Information |
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| BoMiProt ID | Bomi8554 |
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| Protein Name | Pyruvate carboxylase, mitochondrial/Pyruvic carboxylase/PCB |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RK2 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_808815.2 |
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| Aminoacid Length | 1178 |
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| Molecular Weight | 129698 |
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| FASTA Sequence |
Download |
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| Gene Name | PC |
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| Gene ID | 338471 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate |
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| Significance in milk | Expression changes during transition to lactation and feed restriction in dairy cows |
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| PTMs | Acetylation and Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Acetylation of Lys-748 might play a role in catalytic activity regulation |
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| Bibliography | Agca, C., Bidwell, C. A., & Donkin, S. S. (2004). Cloning of bovine pyruvate carboxylase and 5' untranslated region variants. Animal biotechnology, 15(1), 47–66. https://doi.org/10.1081/ABIO-120037897 |
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