Primary Information |
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| BoMiProt ID | Bomi8553 |
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| Protein Name | Pyrroline-5-carboxylate reductase 1, mitochondrial/P5C reductase 1/P5CR 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q58DT4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001014957.1 |
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| Aminoacid Length | 320 |
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| Molecular Weight | 33454 |
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| FASTA Sequence |
Download |
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| Gene Name | PYCR1 |
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| Gene ID | 539606 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | proline biosynthesis.response to oxidative stress |
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| Biochemical Properties | Can utilize both NAD and NADP, but has higher affinity for NAD. converts pyrroline-5-carboxylate to proline |
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| Significance in milk | important amino acid for the mammary secretory process, especially casein synthesis. |
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| PTMs | acetylation on ser,phosphorylation on ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q58DT4|P5CR1_BOVIN Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Bos taurus OX=9913 GN=PYCR1 PE=2 SV=1
MSVGFIGAGQLAFALAKGFTAAGVVAAHKIMASSPDMDLATVSALRKMGVNLTHHNKETV
QHSDVLFLAVKPHIIPFILDEIAANIEARHIVVSCAAGVTISSIEKKLTAFQPAPKVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIH
ALHVLESGGFRSLLIKAVEASCTRTRELQSMADQEKVS*278PAAIKKTILDKVKLDSPPGTSL
APSGHSKLLPRSMAPAGKQD
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| Predicted Disorder Regions | 273-320 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Yeh GC, Harris SC, Phang JM. Pyrroline-5-carboxylate reductase in human erythrocytes. J Clin Invest. 1981 Apr;67(4):1042-6. doi: 10.1172/jci110115. PMID: 6894153; PMCID: PMC370662. |
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