Primary Information |
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BoMiProt ID | Bomi8553 |
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Protein Name | Pyrroline-5-carboxylate reductase 1, mitochondrial/P5C reductase 1/P5CR 1 |
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Organism | Bos taurus |
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Uniprot ID | Q58DT4 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001014957.1 |
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Aminoacid Length | 320 |
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Molecular Weight | 33454 |
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FASTA Sequence |
Download |
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Gene Name | PYCR1 |
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Gene ID | 539606 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Protein Function | proline biosynthesis.response to oxidative stress |
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Biochemical Properties | Can utilize both NAD and NADP, but has higher affinity for NAD. converts pyrroline-5-carboxylate to proline |
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Significance in milk | important amino acid for the mammary secretory process, especially casein synthesis. |
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PTMs | acetylation on ser,phosphorylation on ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q58DT4|P5CR1_BOVIN Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Bos taurus OX=9913 GN=PYCR1 PE=2 SV=1
MSVGFIGAGQLAFALAKGFTAAGVVAAHKIMASSPDMDLATVSALRKMGVNLTHHNKETV
QHSDVLFLAVKPHIIPFILDEIAANIEARHIVVSCAAGVTISSIEKKLTAFQPAPKVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIH
ALHVLESGGFRSLLIKAVEASCTRTRELQSMADQEKVS*278PAAIKKTILDKVKLDSPPGTSL
APSGHSKLLPRSMAPAGKQD
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Predicted Disorder Regions | 273-320 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Yeh GC, Harris SC, Phang JM. Pyrroline-5-carboxylate reductase in human erythrocytes. J Clin Invest. 1981 Apr;67(4):1042-6. doi: 10.1172/jci110115. PMID: 6894153; PMCID: PMC370662. |