Search by BoMiProt ID - Bomi8551


Primary Information

BoMiProt ID Bomi8551
Protein Name Pyridoxal phosphate homeostasis protein/Proline synthase co-transcribed bacterial homolog protein/Pyridoxal phosphate-binding protein
Organism Bos taurus
Uniprot IDQ3T0G5
Milk FractionWhey
Ref Sequence ID NP_001029529.1
Aminoacid Length 273
Molecular Weight 29943
FASTA Sequence Download
Gene Name PLPBP/PROSC
Gene ID 509643
Protein Existence Status reviewed

Secondary Information

Protein Function This protein family plays a significant role in the homeostasis of vitamin B6 and amino acids. 
Biochemical Properties The crystal structures of YggS protein family members, E. coli YggS ,Saccharomyces cerevisiae Ybl036c and Synechococcus elongatus PCC 7942 PipY demonstrated that the proteins bind to PLP via Schiff base linkage with a lysine residue and exhibit structural similarity with the N -terminal domain of bacterial alanine racemase (ALR) and eukaryotic ornithine decarboxylase (ODC), both of which are classified as fold-type III PLP enzymes.
PTMs Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q3T0G5|PLPHP_BOVIN Pyridoxal phosphate homeostasis protein OS=Bos taurus OX=9913 GN=PLPBP PE=2 SV=1 MWKAGS*6MSAELGIGFALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYSH GQRTFGENY*69VQELLEKASNPQILSSCPEIKWHFIGHLQKQNVNKLMAVPNLSMLETVDSV KLADKVNSAWQKKGSPERLKVMVQINTSGEASKHGLPPAEMAALVEHINAKCPSLEFVGL MTIGSFGHDLSQGPNPDFQVLLSLREELCRKLGAPPEQVELSMGMS*226VDFQHAIEVGSTNV RIGS*244TIFGERDYSKKTDKPAAELQAPEEVAQAH
Predicted Disorder Regions 1-7, 250-273
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments The deletion or mutation of a member of this protein family causes pleiotropic effects in many organisms and is causative of vitamin B6-dependent epilepsy in humans
Bibliography 1.Ito T, Yamamoto K, Hori R, Yamauchi A, Downs DM, Hemmi H, Yoshimura T. Conserved Pyridoxal 5'-Phosphate-Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5'-Phosphate in Escherichia coli. Appl Environ Microbiol. 2019 May 16;85(11):e00430-19. doi: 10.1128/AEM.00430-19. PMID: 30902856; PMCID: PMC6532037.