Primary Information
BoMiProt ID	Bomi8540
Protein Name	Putative sodium-coupled neutral amino acid transporter 7
Organism	Bos taurus
Uniprot ID	A7E3U5
Milk Fraction	Whey
Ref Sequence ID	NP_001093825.1
Aminoacid Length	463
Molecular Weight	49853
FASTA Sequence	Download
Gene Name	SLC38A7
Gene ID	513110
Protein Existence Status	Reviewed
Secondary Information
Protein Function	arginine sensor that regulates the mTORC1 signaling pathway on the lysosome membrane.Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|A7E3U5|S38A7_BOVIN Putative sodium-coupled neutral amino acid transporter 7 OS=Bos taurus OX=9913 GN=SLC38A7 PE=2 SV=1 MAQVSINRDLGEWGLSTDSGERARLLQS*28PSVDIAPKSEGEAPPGGVGGGTTSTLGAIFIV VNACLGAGLLNFPAAFSTAGGVAAGITLQMAMLVFIISGLVILAYCSQASNERTYQEVVW AVCGKLTGVLCEVAIATYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGPGGSPWYTDRKFT ISLTAFLFILPLSIPREIGFQKYASFLSVVGTWYVTAIIIIKYIWPDKEMTPADILNRPA SWIAVFNAMPTICFGFQCHVSSVPVFNSMRQPEVKTWGGVVTAAMVIALAVYMGTGICGF LTFGDAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVIEGLWLRYQGMPV EEDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFVFPGLCLIQAKL SEMEEVKPASWWAMVSYGVLLVTLGAFIFGQTTANAIFVDLLA
Predicted Disorder Regions	(6-50)
DisProt Annotation
TM Helix Prediction	11TMHs; (54-76), (85-107), (128-150), (178-196), (203-225), (244-266), (279-301), (320-342), (372-390), (394-416), (429-451)
Significance of PTMs	In goat fibroblast cells,phosphorylation on serine 30 on SLC38A7 is important for mechanism of amino acids and other ions transport in cells.
Bibliography	1.Zheng, X., Su, H., Wang, L., Yao, R., Ma, Y., Bai, L., ... & Wang, Z. (2021). Phosphoproteomics Analysis Reveals a Pivotal Mechanism Related to Amino Acid Signals in Goat Fetal Fibroblast. Frontiers in veterinary science, 860. 2.Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166