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Primary Information | |
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| BoMiProt ID | Bomi8525 |
| Protein Name | Purine nucleoside phosphorylase/Inosine phosphorylase/Inosine-guanosine phosphorylase |
| Organism | Bos taurus |
| Uniprot ID | P55859 |
| Milk Fraction | Whey |
| Aminoacid Length | 289 |
| Molecular Weight | 32037 |
| FASTA Sequence | Download |
| Gene Name | PNP/NP |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | involved in the pathway purine nucleoside salvage, which is part of Purine metabolism |
| Biochemical Properties | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. |
| PTMs | Acetylation and Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P55859|PNPH_BOVIN Purine nucleoside phosphorylase OS=Bos taurus OX=9913 GN=PNP PE=1 SV=3 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL ITNKVIMDYES*251QGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : Phosphorylase/hydrolase-like Superfamily : Purine and uridine phosphorylases Family : Purine and uridine phosphorylases Domain Name : 4PNP A:1-284 |
| CATH | Matched CATH superfamily 3.40.50.1580 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1A9O,1A9P,1A9Q,1A9R,1A9S,1A9T,1B8N,1B8O,1FXU,1LV8,1LVU,1PBN,1V48,1VFN,2AI1,2AI2,2AI3,2QPL,3FUC,3PNP,4PNP., |
| Additional Comments | PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency. |
| Bibliography | Silva RG, Nunes JE, Canduri F, Borges JC, Gava LM, Moreno FB, Basso LA, Santos DS. Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases. Curr Drug Targets. 2007 Mar;8(3):413-22. doi: 10.2174/138945007780058997. PMID: 17348834. |