Primary Information |
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BoMiProt ID | Bomi8495 |
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Protein Name | Proto-oncogene c-Fos |
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Organism | Bos taurus |
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Uniprot ID | O77628 |
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Milk Fraction | whey |
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Ref Sequence ID | NP_877587.1 |
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Aminoacid Length | 380 |
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Molecular Weight | 40737 |
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FASTA Sequence |
Download |
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Gene Name | FOS |
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Gene ID | 280795 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Protein Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling |
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PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|O77628|FOS_BOVIN Protein c-Fos OS=Bos taurus OX=9913 GN=FOS PE=2 SV=2
MMFSGFNADY*10EASSSRCSSASPAGDSLSYY*30HSPADSFSSMGSPVNAQDYCTDLAVSSANF
IPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAGVMKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAAT*232PESEEAFT
LPLLNDPEPKPSVEPVKSVGSMELKAEPFDDYMFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHGGSLGMGPMATELEPLCT*325PVVTCT*331PSCTTYTSSFVFTYPEADSFPSCAAAHRK
GS*362SSNEPSSDSLSS*374PTLLAL
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Predicted Disorder Regions | 12-45, 90-157, 210-303, 320-326, 342-380 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. |
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Bibliography | Herrera, D. G., & Robertson, H. A. (1996). Activation of c-fos in the brain. Progress in neurobiology, 50(2-3), 83–107. https://doi.org/10.1016/s0301-0082(96)00021-4 |