Primary Information |
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| BoMiProt ID | Bomi8493 |
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| Protein Name | Protocadherin-18 |
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| Organism | Bos taurus |
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| Uniprot ID | A7MB46 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095699.1 |
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| Aminoacid Length | 1134 |
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| Molecular Weight | 125864 |
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| FASTA Sequence |
Download |
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| Gene Name | PCDH18 |
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| Gene ID | 539464 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is a potential calcium-dependent cell-adhesion protein. |
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| Biochemical Properties | only protocadherin member that contains a Y residue in the context of a Q/P motif .contains a motif (centered at Y842) shared with src kinases (QGQYQP) that is required for the inhibitory phenotype. |
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| PTMs | Glycosylation on Asn,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7MB46|PCD18_BOVIN Protocadherin-18 OS=Bos taurus OX=9913 GN=PCDH18 PE=2 SV=1
MYQMNAKMHFTFVFALLVVSFNLDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLVKLPN
PSTVRFRAMQRGNTPLLVVNEDNGEISIGAKIDREQLCQKNLN*103CSIEFDVITLPTEHLQL
FHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSAND
FFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSN
DNSPAFEQQSYIIQLLENSPVGTLLLDLN*269ATDPDEGANGKIVYSFSSHVSPKIIETFKID
SERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMS
PGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTN
ATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFAISENNSP
GAYITTVTATDPDLGENGQVTYTILESFILGSSITTYDTIDPSNGAIYALRIFDHEEVSQ
ITFVVEARDGGSPKQLVSN*559TTVVLTIIDENDNVPVVIGPALRNNTAEISIPKGAESGFHV
TRIRAIDRDSGVNAELSCSIVAGNEENIFVIDPRSCDIHTNVSMESVPYTEWELSVVIQD
KGNPQLHTKVLLKCVIFEYAESVTSTAMTSVSQAPLDVSMIIIISLGAICAVLLVIMVLF
ATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRSSPS
SSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQG
QYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGF
SDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQ
HPHQSLEDDVQPVDSGEKKKSFSTFGKDSPSEEDSGDTSTSSLLSEMSSVFQRLLPASLD
TYSECTEMDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTNNSGPPLGTHSSVQP
SSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS
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| Predicted Disorder Regions | 779-907, 933-1101 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (698-720) |
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| Significance of PTMs | phosphorylation at a tyrosine motif (Y842) by src kinases is important for interaction with many factors and also imp for pcdh18 inhibitory phenotype in transfected T cells. |
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| Bibliography | 1.Vazquez-Cintron EJ, Monu NR, Burns JC, Blum R, Chen G, Lopez P, Ma J, Radoja S, Frey AB. Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells. PLoS One. 2012;7(5):e36101. doi: 10.1371/journal.pone.0036101. Epub 2012 May 2. PMID: 22567129; PMCID: PMC3342238. |
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