Primary Information |
|---|
| BoMiProt ID | Bomi8452 |
|---|
| Protein Name | Protein VAC14 homolog |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | A2VE70 |
|---|
| Milk Fraction | Exosomes |
|---|
| Ref Sequence ID | NP_001075913.1 |
|---|
| Aminoacid Length | 783 |
|---|
| Molecular Weight | 87843 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | VAC14 |
|---|
| Gene ID | 533202 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. |
|---|
| Biochemical Properties | Forms pentamers.Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 5-phosphate (PtdIns5P).The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex. |
|---|
| PTMs | Acetylation, Phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VE70|VAC14_BOVIN Protein VAC14 homolog OS=Bos taurus OX=9913 GN=VAC14 PE=2 SV=1
MNPEKDFAPLT*11PNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEF
ALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNI
VKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVL
GEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGI
LTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAK
QEGAASGGPDGSCDSSFSSGISVFTPASAERAPVTLHLDGIVQVLNCHLSDTAIGMMTRI
AVLKWLYHLYIKTPRKMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDD
PGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECS*518PSTPTMNSYFYKFMINLLKRFS
SERKLLEVRGAFIIRQLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTEL
FQLRNQLKDLKTPESRNLFCCLYRSWCHKPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTV
DFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQC
VPNPELLQTEDGLKAAPKSQKADS*744PSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRR
VVL
|
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | 4TMHs;(31-53),(68-90),(97-119),(148-170) |
|---|
