Primary Information |
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| BoMiProt ID | Bomi8429 |
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| Protein Name | Protein strawberry notch homolog 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A0JND4 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001071379.1 |
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| Aminoacid Length | 1374 |
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| Molecular Weight | 150374 |
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| FASTA Sequence |
Download |
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| Gene Name | SBNO2 |
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| Gene ID | 512682 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Predominantly on the astrocytes of CNS |
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| Protein Function | inflammatory response factor,to be a component of the IL10 pathway that represses inflammatory gene expression.Sbno2 plays a pivotal role in bone homeostasis in vivo by fine-tuning osteoclast fusion. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 82-106, 169-215, 1337-1374 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Sbno2-null mice were osteopetrotic, with increases in trabecular bone volume and number and impaired osteoblastogenesis. Fusion of osteoclasts was also impaired in Sbno2-null mice, as was the formation of multinucleated osteoclasts in response to Rankl. |
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| Bibliography | Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med. 2013 Sep 23;210(10):1947-60. doi: 10.1084/jem.20130512. Epub 2013 Aug 26. PMID: 23980096; PMCID: PMC3782043. |
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