Search by BoMiProt ID - Bomi8429

Primary Information

BoMiProt ID Bomi8429
Protein Name Protein strawberry notch homolog 2
Organism Bos taurus
Uniprot IDA0JND4
Milk FractionWhey,MFGM
Ref Sequence ID NP_001071379.1
Aminoacid Length 1374
Molecular Weight 150374
FASTA Sequence Download
Gene Name SBNO2
Gene ID 512682
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Predominantly on the astrocytes of CNS
Protein Function inflammatory response factor,to be a component of the IL10 pathway that represses inflammatory gene expression.Sbno2 plays a pivotal role in bone homeostasis in vivo by fine-tuning osteoclast fusion.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 82-106, 169-215, 1337-1374
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Sbno2-null mice were osteopetrotic, with increases in trabecular bone volume and number and impaired osteoblastogenesis. Fusion of osteoclasts was also impaired in Sbno2-null mice, as was the formation of multinucleated osteoclasts in response to Rankl.
Bibliography Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med. 2013 Sep 23;210(10):1947-60. doi: 10.1084/jem.20130512. Epub 2013 Aug 26. PMID: 23980096; PMCID: PMC3782043.