Search by BoMiProt ID - Bomi8416

Primary Information

BoMiProt ID Bomi8416
Protein Name Protein S100-A1/S-100 protein alpha chain/S-100 protein subunit alpha/S100 calcium-binding protein A1
Organism Bos taurus
Uniprot IDP02639
Milk FractionWhey
Ref Sequence ID NP_001092512.1
Aminoacid Length 94
Molecular Weight 10518
FASTA Sequence Download
Gene Name S100A1
Gene ID 528735
Protein Existence Status Reviewed

Secondary Information

Protein Function Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes.
Significance in milk major constituents of the bovine teat canal lining
PTMs Glutathionylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Pair of EF Hands-like
Superfamily : EF-hand
Family : S100 proteins
Domain Name : 2JPT A:1-93

CATH Matched CATH superfamily
Predicted Disorder Regions 1-5, 20-32, 47-53, 91-94
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs glutathionylation increases affinity to calcium about 10-fold.
Bibliography Kuwano, R., Maeda, T., Usui, H., Araki, K., Yamakuni, T., Ohshima, Y., Kurihara, T., & Takahashi, Y. (1986). Molecular cloning of cDNA of S100 alpha subunit mRNA. FEBS letters, 202(1), 97–101.