Primary Information |
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BoMiProt ID | Bomi8376 |
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Protein Name | Protein odd-skipped-related 1 |
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Organism | Bos taurus |
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Uniprot ID | Q08DS3 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001070384.2 |
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Aminoacid Length | 267 |
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Molecular Weight | 29626 |
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FASTA Sequence |
Download |
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Gene Name | OSR1/ODD1 |
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Gene ID | 539430 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Odd-skipped related 1 (Osr1) is known to play important roles in embryonic, heart, and urogenital development. It is also an essential regulator of heart and urogenital development |
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Biochemical Properties | Mouse Osr1 has a 65% homology with Osr2, whereas their tissue distribution difers. Human Osr1 has been detected in fetal lung, adult colon, small intestine, prostate, and testis tissues is specifcally expressed in limb, tooth, and kidney tissues . |
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PTMs | Methylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Odd 1(-/-) mutant mouse embryos fail to form atrial septum, display dilated atria with hypoplastic venous valves, and exhibit blood backflow from the heart into systemic veins. |
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Bibliography | 1.Kawai S, Yamauchi M, Amano A. Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation. J Bone Miner Metab. 2018 Nov;36(6):640-647. doi: 10.1007/s00774-017-0885-9. Epub 2017 Dec 12. PMID: 29234951. 2.Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R. Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Dev Biol. 2005 Dec 15;288(2):582-94. doi: 10.1016/j.ydbio.2005.09.024. Epub 2005 Oct 11. PMID: 16223478; PMCID: PMC3869089. |