Primary Information
BoMiProt ID	Bomi8368
Protein Name	Protein Mpv17
Organism	Bos taurus
Uniprot ID	Q2KIN6
Milk Fraction	Whey
Ref Sequence ID	NP_001039394.1
Aminoacid Length	176
Molecular Weight	19586
FASTA Sequence	Download
Gene Name	MPV17
Gene ID	505763
Protein Existence Status	reviewed
Secondary Information
Protein Function	Human Mpv17-like protein (M-LPH/Mpv17L) is thought to play a role in minimizing mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage
Biochemical Properties	A high degree of conservation has been determined between MPV17 and its mouse (Mpv17), zebrafish (tra) and yeast (SYM1) homologs, respectively, whereby mutants in these cause very different phenotypes. M-LPH, which has structural features atypical of PDE family members, might be a novel human PDE involved in cAMP/PKA signaling in the mitochondrial matrix.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1-7, 40-43, 80-87
DisProt Annotation
TM Helix Prediction	3TMHs; (51-73),(94-116),(135-157)
Additional Comments	Mpv17 protein forms a channel in the inner mitochondrial membrane, allowing small molecules - in vertebrates probably nucleotides, and in yeast probably intermediates of the tricarboxylic acid cycle - to pass.
Bibliography	1.Iida R, Ueki M, Yasuda T. Human Mpv17-like protein with a mitigating effect on mtDNA damage is involved in cAMP/PKA signaling in the mitochondrial matrix. Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118792. doi: 10.1016/j.bbamcr.2020.118792. Epub 2020 Jul 2. PMID: 32621840. 2.Löllgen S, Weiher H. The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species. Biol Chem. 2015 Jan;396(1):13-25. doi: 10.1515/hsz-2014-0198. PMID: 25205723.