Search by BoMiProt ID - Bomi8366

Primary Information

BoMiProt ID Bomi8366
Protein Name Protein MMS22-like/Methyl methanesulfonate-sensitivity protein 22-like
Organism Bos taurus
Uniprot IDE1BGH8
Milk FractionWhey
Aminoacid Length 1244
Molecular Weight 142274
FASTA Sequence Download
Gene Name MMS22L
Protein Existence Status reviewed

Secondary Information

Protein Function Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks.
Biochemical Properties C6ORF167/MMS22L as a putative human ortholog of yeast Mms22 and on the one hand, there are striking functional similarities between MMS22L and yeast Mms22.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication. 
Bibliography Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 Nov 4. PMID: 21055984.