Primary Information
BoMiProt ID	Bomi8366
Protein Name	Protein MMS22-like/Methyl methanesulfonate-sensitivity protein 22-like
Organism	Bos taurus
Uniprot ID	E1BGH8
Milk Fraction	Whey
Aminoacid Length	1244
Molecular Weight	142274
FASTA Sequence	Download
Gene Name	MMS22L
Protein Existence Status	reviewed
Secondary Information
Protein Function	Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks.
Biochemical Properties	C6ORF167/MMS22L as a putative human ortholog of yeast Mms22 and on the one hand, there are striking functional similarities between MMS22L and yeast Mms22.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	no TM helices
Additional Comments	Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication.
Bibliography	Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 Nov 4. PMID: 21055984.