Primary Information
BoMiProt ID	Bomi8358
Protein Name	Protein kintoun/Dynein assembly factor 2, axonemal
Organism	Bos taurus
Uniprot ID	Q0VC73
Milk Fraction	Whey
Ref Sequence ID	NP_001069492.2
Aminoacid Length	829
Molecular Weight	90970
FASTA Sequence	Download
Gene Name	DNAAF2/KTU
Gene ID	534465
Protein Existence Status	reviewed
Secondary Information
Protein Function	Required for cytosolic pre-assembly of axonemal dyneins and play a central role in motility in cilia and flagella.
Biochemical Properties	Its homologue in single-celled alga Chlamydomonas is known as PF13.
PTMs	Phosphorylation at Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q0VC73|KTU_BOVIN Protein kintoun OS=Bos taurus OX=9913 GN=DNAAF2 PE=2 SV=2 MAKEAASSPLEDLDLSGEEVQRLTSAFQDPEFRRMFSEYAEELTDPENRRRYEEEITALE RERGVEVRFVHPEPGHVLRTSLDGTRRCFVNVCSNALVGAPSSQPGSGSAVSGRQWSLPY SLAPGREYAWGRGTRYTVYDVVFHPDAIALARRHERFRQMLDATALEAVEKQFGVKLDRR NAKTLKIKYKGTPDAAVLRTPLPGGAPARPEGEPESPFPDFPYPYRYPAAGASAAVPRPQ APSPPEAVRQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPGTVPQELVVTIELPLLRSAEQ AALEVTGKLLCLDSRKPDYRLRLSLPYPVDDSRGKAQFNKARRQLVVTLPVAPTASRPEP AASPEEAADPPGTDGAACASACRGEAGPAGVCAGDAISGPSRTRAADAGITTPDAPGKER VAKSEERDFGGQEISTTGTREEPPSGAGNS*450PGDRGGGALSTSWGDLDAGLSVGSASVRPT LGVEARETREGTGREPAYRAMGGPGTDRGEALCPPLQCSQDEESLTLLVQVPWILLQSLQ GEVNPLWYKLSFSTQDLVYYSFFLQFTPENKLSTKEPEVSISSNNAVINLAKSPECHGYW REWYYGLNNYCLEERLFVNEDNVNEFLEEVLS*632PPFKQTLPLTPPLIEVLQVTDSKIEIHA KLQECSNSEQLHEKEERVHEGSPLTEKENTEHATISTTDSASSVAVTVLEADRCGSATCL QQGALDVSQKLFAESQQPKSEKEREFIKDKSAVYANERKDNLKEPVITEEKELDGNHPSS LLNKTAVRDTPGFDHIKETNMQDGSVQIIKDHVTHCSFSFQNNLLYDLD
Predicted Disorder Regions	1-11, 222-238, 256-274, 365-469, 490-504, 675-702, 718-758, 781-785
DisProt Annotation
TM Helix Prediction	no TM helices
Additional Comments	A mutation in Ktu/PF13 has been identified in some patients with primary ciliary dyskinesia (PCD).
Bibliography	Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H. Nature 456, 611-6, (2008). View articlePMID: 19052621