Primary Information |
|---|
| BoMiProt ID | Bomi8352 |
|---|
| Protein Name | Protein kinase C and casein kinase substrate in neurons protein 1 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | A7MBI0 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001094571.1 |
|---|
| Aminoacid Length | 444 |
|---|
| Molecular Weight | 50658 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | PACSIN1 |
|---|
| Gene ID | 520488 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | regulates the dynamics of AMPA receptors trafficking.regulating activity-dependent endocytosis and the recycling of presynaptic vesicles. |
|---|
| Biochemical Properties | F-BAR (elongated BAR) and SH3 (src homology-3) domain-containing protein that is capable of remodeling the plasma membrane and mediating protein-protein interactions |
|---|
| PTMs | phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7MBI0|PACN1_BOVIN Protein kinase C and casein kinase substrate in neurons protein 1 OS=Bos taurus OX=9913 GN=PACSIN1 PE=2 SV=1
MS*2GSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQL
TDWAKRWRQLLEKGPQYGS*79LERAWGAIMTEADKVSELHQEMKNSLLNEDLEKVKNWQKDA
YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAVTREMNSKTE
QSVT*184PEQQKKLQDKVDKCKQDVQKTQEKYEKVLDDVGKTTPQYMEGMEQVFEQCQQFEEK
RLVFLKEVLLDIKRHLNLAESSSYVQVYRELEQAIRGADAQDDLRWFRSTSGPGMPMNWP
QFEEWNPDLPHTAAKKEKQPKKAEGAALTNAAGVVESTSQAGDRGS*346VS*348S*349YDRGQTYATEW
S*361DDES*365GNPFGGSEANGGSNPFDEDAKGVRVRALY*394DYDGQEQDELS*405FKAGDELTKLGEEDEQGWCRGRLDS*430GQLGLYPANYVEVV
|
|---|
| Predicted Disorder Regions | 1-16, 149-152, 175-205, 344-371, 386-407, 419-421 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
|---|
| Bibliography | Widagdo J, Fang H, Jang SE, Anggono V. PACSIN1 regulates the dynamics of AMPA receptor trafficking. Sci Rep. 2016 Aug 4;6:31070. doi: 10.1038/srep31070. PMID: 27488904; PMCID: PMC4973260. |
|---|
