Primary Information |
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| BoMiProt ID | Bomi8338 |
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| Protein Name | Protein HEXIM1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0X0C4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069649.1 |
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| Aminoacid Length | 320 |
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| Molecular Weight | 36317 |
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| FASTA Sequence |
Download |
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| Gene Name | HEXIM1 |
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| Gene ID | 539696 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | human vascular smooth muscle cells |
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| Protein Function | inhibitor of transcription. tumor suppressor.non-coding RNA-dependent regulator of transcription.7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). |
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| Biochemical Properties | The Hexim1 basic region (BR) or Arginine-Rich Motif (ARM) is involved in 7SK RNA binding |
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| Significance in milk | inhibits bovine immunodeficiency virus replication |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0X0C4|HEXI1_BOVIN Protein HEXIM1 OS=Bos taurus OX=9913 GN=HEXIM1 PE=2 SV=1
MAEPLLSEFQHQPQTSNCTGAVAVHEERNPDRPPGAEERVPEEDSRWQSRASPKSGGSPG
HGGEGSLEPQPSPLKTQVCPESSCPEAGEKGQNGDDLS*98AGGAPPQQRQVGKKKHRRRPSK
KKRLWKPYYTLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPD
LKTGLYPKRAAAKS*194DDT*197S*198DEDFMEEAGEEDGGS*213DGMGGDGS*221EFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESQRLDGDDARVRELELELDRLRAENLQL
LTENELHRQQERAPLSNFGD
|
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| Predicted Disorder Regions | 1-320 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Michels AA, Bensaude O. Hexim1, an RNA-controlled protein hub. Transcription. 2018;9(4):262-271. doi: 10.1080/21541264.2018.1429836. Epub 2018 Feb 23. PMID: 29345523; PMCID: PMC6104690. |
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