Primary Information |
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| BoMiProt ID | Bomi8325 |
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| Protein Name | Protein disulfide-isomerase A3/58 kDa glucose-regulated protein/58 kDa microsomal protein/p58/Disulfide isomerase ER-60/Endoplasmic reticulum resident protein 57/ER protein 57/Endoplasmic reticulum resident protein 60 |
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| Organism | Bos taurus |
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| Uniprot ID | P38657 |
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| Milk Fraction | Whey,MFGM |
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| Aminoacid Length | 505 |
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| Molecular Weight | 56930 |
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| FASTA Sequence |
Download |
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| Gene Name | PDIA3/GRP58 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | for mediating the rapid cellular responses of vitamin D, in intestinal epithelia,involved in stimulation of calcium and phosphate intake. |
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| Biochemical Properties | has three catalytic activities including, thiol-disulfide oxireductase, disulfide isomerase and redox-dependent chaperon.has three catalytic activities including, thiol-disulfide oxireductase, disulfide isomerase and redox-dependent chaperon.The two redox active sites containing the CXXC motif are found in the a and a' domains.The two redox active sites containing the CXXC motif are found in the a and a' domains |
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| PTMs | phosphorylation,Acetylation,Methylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 OS=Bos taurus OX=9913 GN=PDIA3 PE=2 SV=1
MRLRRLALFPGLALLLAAARLAAASDVLELTDDNFESRITDTGSSGLMLVEFFAPWCGHC
KKLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEESGAYDGPRT
ADGIVSHLKKQAGPASVPLKSEEEFEKFISDKDASVVGFFKDLFSEAHSEFLKAASNLRD
NYRFAHTNVESLVNKYDDDGEGITLFRPSHLTNKFEDKTVAYTEQKMTSGKIKRFIQENI
FGICPHMTEDNKDLLQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGQKLHFA
VASRKTFSHELSDFGLEST*319TGEIPVVAVRTAKGEKFVMQEEFSRDGKALERFLEDYFDGN
LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG
EKLRKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFISYL
KREATNPPVIQEEKPKKKKKAQEDL
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| Predicted Disorder Regions | 127-146, 484-505 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Yavuz U, Alaylıoğlu M, Şengül B, Karras SN, Gezen-Ak D, Dursun E. Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons. In Vitro Cell Dev Biol Anim. 2021 Aug;57(7):704-714. doi: 10.1007/s11626-021-00602-5. Epub 2021 Aug 2. PMID: 34338991. |
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