Primary Information
BoMiProt ID	Bomi8322
Protein Name	Protein CASC3/Cancer susceptibility candidate gene 3 protein/Metastatic lymph node gene 51 protein homolog/Protein barentsz
Organism	Bos taurus
Uniprot ID	A5D7H5
Milk Fraction	Whey
Ref Sequence ID	NP_001091538.1
Aminoacid Length	703
Molecular Weight	76147
FASTA Sequence	Download
Gene Name	CASC3/MLN51
Gene ID	531673
Protein Existence Status	reviewed
Secondary Information
Protein Function	It is a component of the spliceosome assambly and has a role in pre-mRNA splicing.
PTMs	Phosphorylation, ADP Ribosylation, Ubiquitinylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|A5D7H5|CASC3_BOVIN Protein CASC3 OS=Bos taurus OX=9913 GN=CASC3 PE=2 SV=1 MADRRRQRASQDTEDEESGASGSDSGGSPARGGGS*35CSGSVGGGGSGSLPSQRGGRAGALH LRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGDDGEYSEEENSKVELKS*117EAN DAANSSAKDEKGEEKPDTKGTVTGERQS*148GDGQESTEPVENKVGKKGPKHLDDDEDRKNPA YIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALY GYDIRSAHNPDDIKPRRIRKPRFGS*265PPQRDPSWIGERPNKSHRHQGPGGTLPPRTFINRN AAGTGRMSAPRNYSRSGGFKEGRTGFRPAEAGGQHAGRSGETVKHETSYRSRHLEQT*357PVR DPS*363PEADAQVLGS*373PEKEEVAPEIPNPAPDTAPPVPDRPVEKKSYSRARRTRIKAGDAGKV AEEVPPPPEGLTPAPPVPEATPPTPAKTGNWEAPVDSTTGGLEQDVAQLNITEQNWS*477PGQ PAFLQSRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHI SIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQTPAPLPNPGLY PPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQV YGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS
Predicted Disorder Regions	(1-175), (252-277), (346-366)
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination
Bibliography	Cougot, N., Daguenet, E., Baguet, A., Cavalier, A., Thomas, D., Bellaud, P., Fautrel, A., Godey, F., Bertrand, E., Tomasetto, C., & Gillet, R. (2014). Overexpression of MLN51 triggers P-body disassembly and formation of a new type of RNA granules. Journal of cell science, 127(Pt 21), 4692–4701. https://doi.org/10.1242/jcs.154500